LS mean changes from baseline to 4 y in hematological, visceral, and bone parameters from repeated-measures mixed model
| Parameter . | LS mean (95% CI) . | LS mean change from baseline (95% CI) . | P value . |
|---|---|---|---|
| Hemoglobin, g/dL | |||
| B (n = 157) | 13.7 (13.6, 13.8) | — | — |
| Year 1 (n = 151) | 13.6 (13.4, 13.7) | −0.11 (−0.27, 0.06) | .21 |
| Year 2 (n = 139) | 13.6 (13.4, 13.7) | −0.09 (−0.27, 0.09) | .31 |
| Year 3 (n = 110) | 13.6 (13.5, 13.8) | −0.04 (−0.23, 0.15) | .67 |
| Year 4 (n = 45) | 13.9 (13.7, 14.1) | 0.23 (−0.02, 0.49) | .07 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .06 |
| Platelet count, ×109/L | |||
| B (n = 157) | 200.3 (194.4, 206.1) | — | — |
| Year 1 (n = 151) | 206.7 (200.7, 212.7) | 6.31 (−1.52, 14.13) | .11 |
| Year 2 (n = 139) | 202.4 (196.2, 208.6) | 2.13 (−6.35, 10.60) | .62 |
| Year 3 (n = 110) | 210.7 (203.8, 217.6) | 10.40 (1.35, 19.45) | .02 |
| Year 4 (n = 45) | 209.9 (199.2, 220.7) | 9.57 (−2.60, 21.74) | .12 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .09 |
| Spleen volume, MN | |||
| B (n = 120) | 3.1 (3.0, 3.2) | — | — |
| Year 1 (n = 115) | 2.9 (2.9, 3.0) | −0.14 (−0.22, −0.05) | .002 |
| Year 2 (n = 105) | 2.9 (2.8, 3.0) | −0.20 (−0.31, −0.09) | .0003 |
| Year 3 (n = 80) | 2.9 (2.8, 3.0) | −0.21 (−0.35, −0.10) | .0003 |
| Year 4 (n = 33) | 2.7 (2.5, 2.8) | −0.39 (−0.55, −0.22) | <.0001 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | <.0001 |
| Liver volume, MN | |||
| B (n = 157) | 0.94 (0.93, 0.96) | — | — |
| Year 1 (n = 151) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .17 |
| Year 2 (n = 136) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .29 |
| Year 3 (n = 110) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .49 |
| Year 4 (n = 46) | 0.91 (0.89, 0.94) | −0.03 (−0.06, −0.004) | .03 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .04 |
| Total spine z score | |||
| B (n = 153) | −0.3 (−0.3, −0.2) | — | — |
| Year 1 (n = 144) | −0.2 (−0.2, −0.1) | 0.07 (0.03, 0.11) | .002 |
| Year 2 (n = 132) | −0.1 (−0.2, −0.09) | 0.11 (0.06, 0.17) | <.0001 |
| Year 3 (n = 104) | −0.09 (−0.1, −0.04) | 0.16 (0.10, 0.23) | <.0001 |
| Year 4 (n = 42) | 0.04 (−0.04, 0.1) | 0.29 (0.20, 0.38) | <.0001 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | <.0001 |
| Total femur z score | |||
| B (n = 151) | 0.03 (−0.007, 0.060) | — | — |
| Year 1 (n = 139) | 0.07 (0.034, 0.103) | 0.04 (0.013, 0.072) | .005 |
| Year 2 (n = 129) | 0.05 (0.018, 0.088) | 0.03 (−0.012, 0.065) | .17 |
| Year 3 (n = 103) | 0.08 (0.044, 0.120) | 0.06 (0.011, 0.101) | .02 |
| Year 4 (n = 39) | 0.07 (0.018, 0.131) | 0.05 (−0.015, 0.111) | .13 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .14 |
| Parameter . | LS mean (95% CI) . | LS mean change from baseline (95% CI) . | P value . |
|---|---|---|---|
| Hemoglobin, g/dL | |||
| B (n = 157) | 13.7 (13.6, 13.8) | — | — |
| Year 1 (n = 151) | 13.6 (13.4, 13.7) | −0.11 (−0.27, 0.06) | .21 |
| Year 2 (n = 139) | 13.6 (13.4, 13.7) | −0.09 (−0.27, 0.09) | .31 |
| Year 3 (n = 110) | 13.6 (13.5, 13.8) | −0.04 (−0.23, 0.15) | .67 |
| Year 4 (n = 45) | 13.9 (13.7, 14.1) | 0.23 (−0.02, 0.49) | .07 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .06 |
| Platelet count, ×109/L | |||
| B (n = 157) | 200.3 (194.4, 206.1) | — | — |
| Year 1 (n = 151) | 206.7 (200.7, 212.7) | 6.31 (−1.52, 14.13) | .11 |
| Year 2 (n = 139) | 202.4 (196.2, 208.6) | 2.13 (−6.35, 10.60) | .62 |
| Year 3 (n = 110) | 210.7 (203.8, 217.6) | 10.40 (1.35, 19.45) | .02 |
| Year 4 (n = 45) | 209.9 (199.2, 220.7) | 9.57 (−2.60, 21.74) | .12 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .09 |
| Spleen volume, MN | |||
| B (n = 120) | 3.1 (3.0, 3.2) | — | — |
| Year 1 (n = 115) | 2.9 (2.9, 3.0) | −0.14 (−0.22, −0.05) | .002 |
| Year 2 (n = 105) | 2.9 (2.8, 3.0) | −0.20 (−0.31, −0.09) | .0003 |
| Year 3 (n = 80) | 2.9 (2.8, 3.0) | −0.21 (−0.35, −0.10) | .0003 |
| Year 4 (n = 33) | 2.7 (2.5, 2.8) | −0.39 (−0.55, −0.22) | <.0001 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | <.0001 |
| Liver volume, MN | |||
| B (n = 157) | 0.94 (0.93, 0.96) | — | — |
| Year 1 (n = 151) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .17 |
| Year 2 (n = 136) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .29 |
| Year 3 (n = 110) | 0.95 (0.94, 0.97) | 0.01 (−0.01, 0.03) | .49 |
| Year 4 (n = 46) | 0.91 (0.89, 0.94) | −0.03 (−0.06, −0.004) | .03 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .04 |
| Total spine z score | |||
| B (n = 153) | −0.3 (−0.3, −0.2) | — | — |
| Year 1 (n = 144) | −0.2 (−0.2, −0.1) | 0.07 (0.03, 0.11) | .002 |
| Year 2 (n = 132) | −0.1 (−0.2, −0.09) | 0.11 (0.06, 0.17) | <.0001 |
| Year 3 (n = 104) | −0.09 (−0.1, −0.04) | 0.16 (0.10, 0.23) | <.0001 |
| Year 4 (n = 42) | 0.04 (−0.04, 0.1) | 0.29 (0.20, 0.38) | <.0001 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | <.0001 |
| Total femur z score | |||
| B (n = 151) | 0.03 (−0.007, 0.060) | — | — |
| Year 1 (n = 139) | 0.07 (0.034, 0.103) | 0.04 (0.013, 0.072) | .005 |
| Year 2 (n = 129) | 0.05 (0.018, 0.088) | 0.03 (−0.012, 0.065) | .17 |
| Year 3 (n = 103) | 0.08 (0.044, 0.120) | 0.06 (0.011, 0.101) | .02 |
| Year 4 (n = 39) | 0.07 (0.018, 0.131) | 0.05 (−0.015, 0.111) | .13 |
| Test for linear trend (B, 1, 2, 3, 4 y) | — | — | .14 |
B, baseline; CI, confidence interval.