Table 4. Discovery of different models... | American Society of Hematology

Table 4.

Discovery of different models of SNPs associated with IA development within 3 months and 2 years after hematopoietic stem cell transplantation; cases defined as either proven/probable or SGM+

Gene	SNP	Allele*	MAF	Phenotype	Genome	Time after transplantation	Model	HR/OR	95% CI	P
PTX3	rs2305619	A/G	0.47	Proven/probable	DNR	2 y	Allelic	1.20	1.04-1.37	.009
				SGM+	DNR	3 mo	Allelic	1.42	1.08-1.86	.01
						3 mo	Recessive	2.44	1.33-4.42	.004
						2 y	Allelic	1.30	1.04-1.641	.022
						2 y	Recessive	1.54	1.02-2.34	.039
PTX3	rs3816527	C/A	0.42	SGM+	DNR	3 mo	Allelic	1.41	1.07-1.87	.015
						3 mo	Recessive	3.29	1.53-7.08	.002
						2 y	Allelic	1.30	1.03-1.61	.024
						2 y	Recessive	1.82	1.11-2.94	.017
CLEC7A	rs16910526	A/C	0.08	Proven/probable	DNR	2 y	Allelic	1.30	1.03-1.65	.03
					PT	3 mo	Allelic	1.69	1.29-2.22	.0001
						3 mo	Dominant	1.77	1.29-2.42	.0003
						2 y	Allelic	1.29	1.03-1.62	.03
						2 y	Dominant	1.30	1.01-1.68	.04
CLEC7A	rs7309123	C/G	0.43	Proven/probable	DNR	2 y	Recessive	1.29	1.02-1.63	.030
CD209	rs7248637	G/A†	0.10	SGM+	DNR	3 mo	Allelic	0.56	0.32-0.97	.042
					PT	3 mo	Allelic	0.54	0.30-0.97	.037
						3 mo	Dominant	0.50	0.27-0.93	.028
						2 y	Allelic	0.65	0.42-0.99	.046
						2 y	Dominant	0.56	0.35-0.91	.018
CXCL10	rs1554013	C/T	0.45	SGM+	PT	3 mo	Allelic	1.38	1.05-1.81	.020
CXCL10	rs1554013	C/T	0.45	SGM+	PT	3 mo	Recessive	1.59	1.04-2.42	.033
CXCL10	rs3921	C/G	0.45	SGM+	PT	3 mo	Allelic	1.35	1.03-1.77	.031
CXCL10	rs3921	C/G	0.45	SGM+	PT	3 mo	Recessive	1.55	1.01-2.36	.044
CXCL10	rs4257674	A/G	0.45	SGM+	PT	3 mo	Allelic	1.35	1.03-1.77	.028
CXCL10	rs4257674	A/G	0.45	SGM+	PT	3 mo	Recessive	1.56	1.02-2.38	.041
TLR6	rs5743810	C/T	0.40	Proven/probable	DNR	2 y	Dominant	1.38	1.12-1.71	.003
TLR6	rs5743810	C/T	0.40	SGM+	DNR	2 y	Dominant	1.41	1.01-1.98	.046
S100B	rs9722	C/T	0.11	SGM+	DNR	3 mo	Allelic	1.66	1.17-2.34	.004
						3 mo	Dominant	1.79	1.19-2.69	.005
						2 y	Allelic	1.47	1.09-1.98	.011
						2 y	Dominant	1.54	1.09-2.17	.013
IFNG	rs2069705	T/C‡	0.34	SGM+	DNR	2 y	Dominant	0.73	0.58-0.99	.045
PLG	rs4252125	G/A	0.28	Proven/probable	DNR	3 mo	Recessive	1.57	1.06-2.33	.026
PLG	rs4252125	G/A	0.28	Proven/probable	DNR	2 y	Recessive	1.39	1.02-1.90	.037
TNFR1	rs4149570	C/A	0.40	SGM+	DNR	3 mo	Recessive	0.53	0.27-1.00	.05

Gene	SNP	Allele*	MAF	Phenotype	Genome	Time after transplantation	Model	HR/OR	95% CI	P
PTX3	rs2305619	A/G	0.47	Proven/probable	DNR	2 y	Allelic	1.20	1.04-1.37	.009
				SGM+	DNR	3 mo	Allelic	1.42	1.08-1.86	.01
						3 mo	Recessive	2.44	1.33-4.42	.004
						2 y	Allelic	1.30	1.04-1.641	.022
						2 y	Recessive	1.54	1.02-2.34	.039
PTX3	rs3816527	C/A	0.42	SGM+	DNR	3 mo	Allelic	1.41	1.07-1.87	.015
						3 mo	Recessive	3.29	1.53-7.08	.002
						2 y	Allelic	1.30	1.03-1.61	.024
						2 y	Recessive	1.82	1.11-2.94	.017
CLEC7A	rs16910526	A/C	0.08	Proven/probable	DNR	2 y	Allelic	1.30	1.03-1.65	.03
					PT	3 mo	Allelic	1.69	1.29-2.22	.0001
						3 mo	Dominant	1.77	1.29-2.42	.0003
						2 y	Allelic	1.29	1.03-1.62	.03
						2 y	Dominant	1.30	1.01-1.68	.04
CLEC7A	rs7309123	C/G	0.43	Proven/probable	DNR	2 y	Recessive	1.29	1.02-1.63	.030
CD209	rs7248637	G/A†	0.10	SGM+	DNR	3 mo	Allelic	0.56	0.32-0.97	.042
					PT	3 mo	Allelic	0.54	0.30-0.97	.037
						3 mo	Dominant	0.50	0.27-0.93	.028
						2 y	Allelic	0.65	0.42-0.99	.046
						2 y	Dominant	0.56	0.35-0.91	.018
CXCL10	rs1554013	C/T	0.45	SGM+	PT	3 mo	Allelic	1.38	1.05-1.81	.020
CXCL10	rs1554013	C/T	0.45	SGM+	PT	3 mo	Recessive	1.59	1.04-2.42	.033
CXCL10	rs3921	C/G	0.45	SGM+	PT	3 mo	Allelic	1.35	1.03-1.77	.031
CXCL10	rs3921	C/G	0.45	SGM+	PT	3 mo	Recessive	1.55	1.01-2.36	.044
CXCL10	rs4257674	A/G	0.45	SGM+	PT	3 mo	Allelic	1.35	1.03-1.77	.028
CXCL10	rs4257674	A/G	0.45	SGM+	PT	3 mo	Recessive	1.56	1.02-2.38	.041
TLR6	rs5743810	C/T	0.40	Proven/probable	DNR	2 y	Dominant	1.38	1.12-1.71	.003
TLR6	rs5743810	C/T	0.40	SGM+	DNR	2 y	Dominant	1.41	1.01-1.98	.046
S100B	rs9722	C/T	0.11	SGM+	DNR	3 mo	Allelic	1.66	1.17-2.34	.004
						3 mo	Dominant	1.79	1.19-2.69	.005
						2 y	Allelic	1.47	1.09-1.98	.011
						2 y	Dominant	1.54	1.09-2.17	.013
IFNG	rs2069705	T/C‡	0.34	SGM+	DNR	2 y	Dominant	0.73	0.58-0.99	.045
PLG	rs4252125	G/A	0.28	Proven/probable	DNR	3 mo	Recessive	1.57	1.06-2.33	.026
PLG	rs4252125	G/A	0.28	Proven/probable	DNR	2 y	Recessive	1.39	1.02-1.90	.037
TNFR1	rs4149570	C/A	0.40	SGM+	DNR	3 mo	Recessive	0.53	0.27-1.00	.05

CI, confidence interval; DNR, donor; HR, hazard ratio; OR, odds ratio; PT, patient.

Major/minor allele.

†

Original study had major/minor alleles A/G.

‡

Original study had major/minor alleles C/T.

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