Clinicopathologic features on presentation and at relapse/refractory disease of 7 patients with NK/T-cell lymphoma treated with pembrolizumab
| Case . | . | . | On initial presentation . | At relapse/refractory disease before pembrolizumab . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | Primary sites . | Marrow . | Stage . | Sites . | ECOG score . | Marrow . | Stage . | HPS . | |
| 1 | M | 68 | Skin of lower limbs, nasal cavities | Negative | IV | Calf skin | 1 | Negative | IE | Nil |
| 2 | M | 49 | Nasal cavities, lymph nodes, liver, spleen, bone | Negative | IV | Liver, spleen | 1 | Positive | IV | Yes |
| 3 | M | 38 | Nasopharynx | Negative | IE | Nasopharynx, hard palate | 2 | Positive | IV | Yes |
| 4 | M | 50 | Liver | Positive | IV | Liver | 3 | Positive | IV | Yes |
| 5 | M | 31 | Nasal cavity, nasopharynx, masseter muscle, bone | Negative | IV | Nasal cavity, liver | 2 | Negative | IV | Yes |
| 6 | M | 35 | Nasal cavity | Negative | IE | Lung, esophagus | 2 | Negative | IV | Nil |
| 7 | M | 51 | Liver, spleen | Positive | IV | Liver | 1 | Positive | IV | Yes |
| Case . | . | . | On initial presentation . | At relapse/refractory disease before pembrolizumab . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sex . | Age, y . | Primary sites . | Marrow . | Stage . | Sites . | ECOG score . | Marrow . | Stage . | HPS . | |
| 1 | M | 68 | Skin of lower limbs, nasal cavities | Negative | IV | Calf skin | 1 | Negative | IE | Nil |
| 2 | M | 49 | Nasal cavities, lymph nodes, liver, spleen, bone | Negative | IV | Liver, spleen | 1 | Positive | IV | Yes |
| 3 | M | 38 | Nasopharynx | Negative | IE | Nasopharynx, hard palate | 2 | Positive | IV | Yes |
| 4 | M | 50 | Liver | Positive | IV | Liver | 3 | Positive | IV | Yes |
| 5 | M | 31 | Nasal cavity, nasopharynx, masseter muscle, bone | Negative | IV | Nasal cavity, liver | 2 | Negative | IV | Yes |
| 6 | M | 35 | Nasal cavity | Negative | IE | Lung, esophagus | 2 | Negative | IV | Nil |
| 7 | M | 51 | Liver, spleen | Positive | IV | Liver | 1 | Positive | IV | Yes |
ECOG, Eastern Cooperative Oncology Group; HPS, hemophagocytic syndrome.