Multivariable Cox regression model for association with OS
| Characteristic* . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| Median OS (mo) . | 95% CI . | 3-y OS (%) . | HR . | 95% CI . | P . | |
| Age at diagnosis, y | <.001 | |||||
| 60-64 | 9 | 8-12 | 24 | 1 | ||
| 65-69 | 7 | 6-9 | 17 | 1.19 | 1.01-1.4 | |
| 70-74 | 5 | 3-6 | 12 | 1.46 | 1.23-1.73 | |
| 75-79 | 3 | 2-4 | 8 | 1.75 | 1.48-2.08 | |
| 80-84 | 1 | 1-2 | 5 | 2.18 | 1.82-2.62 | |
| 85+ | 0 | 0-1 | 4 | 2.89 | 2.4-3.49 | |
| Diagnosis year | <.001 | |||||
| 1980-1989 | 3 | 2-4 | 10 | 1 | ||
| 1990-1999 | 2 | 2-3 | 11 | 1.06 | 0.93-1.21 | |
| 2000-2011 | 6 | 5-7 | 16 | 0.8 | 0.71-0.91 | |
| Prior cancer history | .08 | |||||
| No† | 4 | 3-5 | 13 | 1 | ||
| Yes | 3 | 2-4 | 10 | 1.12 | 0.99-1.27 | |
| Region‡ | .04 | |||||
| East | 6 | 4-7 | 14 | 1 | ||
| Northern Plains | 3 | 2-4 | 11 | 1.21 | 1.05-1.39 | |
| Pacific Coast | 4 | 3-5 | 14 | 1.05 | 0.91-1.21 | |
| Southwest | 4 | 2-7 | 13 | 1.14 | 0.95-1.36 | |
| Characteristic* . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| Median OS (mo) . | 95% CI . | 3-y OS (%) . | HR . | 95% CI . | P . | |
| Age at diagnosis, y | <.001 | |||||
| 60-64 | 9 | 8-12 | 24 | 1 | ||
| 65-69 | 7 | 6-9 | 17 | 1.19 | 1.01-1.4 | |
| 70-74 | 5 | 3-6 | 12 | 1.46 | 1.23-1.73 | |
| 75-79 | 3 | 2-4 | 8 | 1.75 | 1.48-2.08 | |
| 80-84 | 1 | 1-2 | 5 | 2.18 | 1.82-2.62 | |
| 85+ | 0 | 0-1 | 4 | 2.89 | 2.4-3.49 | |
| Diagnosis year | <.001 | |||||
| 1980-1989 | 3 | 2-4 | 10 | 1 | ||
| 1990-1999 | 2 | 2-3 | 11 | 1.06 | 0.93-1.21 | |
| 2000-2011 | 6 | 5-7 | 16 | 0.8 | 0.71-0.91 | |
| Prior cancer history | .08 | |||||
| No† | 4 | 3-5 | 13 | 1 | ||
| Yes | 3 | 2-4 | 10 | 1.12 | 0.99-1.27 | |
| Region‡ | .04 | |||||
| East | 6 | 4-7 | 14 | 1 | ||
| Northern Plains | 3 | 2-4 | 11 | 1.21 | 1.05-1.39 | |
| Pacific Coast | 4 | 3-5 | 14 | 1.05 | 0.91-1.21 | |
| Southwest | 4 | 2-7 | 13 | 1.14 | 0.95-1.36 | |
HR, hazard ratio.
Patients with unknown classification for any of the included variables were excluded from the multivariable survival analysis.
Patients in whom ALL was the only malignancy diagnosed, or the first malignancy of ≥2 malignancies were identified as having “no prior cancer history” at the time of diagnosis of ALL.
East: Atlanta, GA, and Connecticut; Northern Plains: Detroit, MI, and Iowa; Pacific Coast: San Francisco, CA, Hawaii, and Seattle, WA; Southwest: New Mexico and Utah.