Table 1

Hematological parameters of wild-type, MRI49372/+, and MRI49372 mice

WTMRI49372m/+MRI49372m/m
WBC 9.6 ± 0.7 10.6 ± 0.5 20.2 ± 2.3** 
RBC 10.3 ± 0.2 8.8 ± 0.4 5.9 ± 0.4*** 
HGB 106.1 ± 8.2 93.0 ± 7.7 71.2 ± 7.9** 
MCV 53.1 ± 0.5 56.2 ± 0.4* 71.6 ± 2.1* 
RDW 14.6 ± 0.2 14.1 ± 0.2 21.9 ± 1.0*** 
%Retic 2.3 ± 0.3 6.0 ± 1.1* 52.6 ± 6.5** 
%Macro 0.3 ± 0.1 1.3 ± 0.3** 40.2 ± 5.5*** 
%Micro 0.4 ± 0.04 0.2 ± 0.01*** 0.7 ± 0.1*** 
PLT 897.7 ± 48.7 962.9 ± 64.3 1181.4 ± 59.3* 
WTMRI49372m/+MRI49372m/m
WBC 9.6 ± 0.7 10.6 ± 0.5 20.2 ± 2.3** 
RBC 10.3 ± 0.2 8.8 ± 0.4 5.9 ± 0.4*** 
HGB 106.1 ± 8.2 93.0 ± 7.7 71.2 ± 7.9** 
MCV 53.1 ± 0.5 56.2 ± 0.4* 71.6 ± 2.1* 
RDW 14.6 ± 0.2 14.1 ± 0.2 21.9 ± 1.0*** 
%Retic 2.3 ± 0.3 6.0 ± 1.1* 52.6 ± 6.5** 
%Macro 0.3 ± 0.1 1.3 ± 0.3** 40.2 ± 5.5*** 
%Micro 0.4 ± 0.04 0.2 ± 0.01*** 0.7 ± 0.1*** 
PLT 897.7 ± 48.7 962.9 ± 64.3 1181.4 ± 59.3* 

Automated full blood analysis on WT (n = 15), SJL/J-Ampd3T689A/+ (n = 21), and SJL/J-Ampd3T689A (n = 14) mice. Values are mean ± SEM.

HGB, total hemoglobin g/L; MCV, mean corpuscular volume (fL); PLT, number of platelets 103 cells/μL; RBC, number of red blood cells × 106 cells/μL; RDW, percentage red cell distribution width; WBC, number of white blood cells × 103 cells/μL; %Macro, % macrocytic cells; %Micro, % microcytic cells; %Retics, % reticulocytes.

*P < .05; **P < .01; ***P < .001.

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