MMB inhibits BMPR kinase ACVR1/ALK2
| Kinase . | MMB IC50 (nM) . | RUX IC50 (nM) . |
|---|---|---|
| JAK1 | 26.9 | 1.2 |
| JAK2 | 1.4 | <0.3 |
| JAK3 | 6.1 | 3.1 |
| TYK2 | 19.9 | 8.5 |
| ACVR1 (ALK2) | 8.4 | 6100 |
| BMPR1a (ALK3) | 405 | >10K |
| TGFBR1 (ALK5) | 205 | 6907 |
| Kinase . | MMB IC50 (nM) . | RUX IC50 (nM) . |
|---|---|---|
| JAK1 | 26.9 | 1.2 |
| JAK2 | 1.4 | <0.3 |
| JAK3 | 6.1 | 3.1 |
| TYK2 | 19.9 | 8.5 |
| ACVR1 (ALK2) | 8.4 | 6100 |
| BMPR1a (ALK3) | 405 | >10K |
| TGFBR1 (ALK5) | 205 | 6907 |
JAK1, JAK2, JAK3, and TYK2 IC50s for MMB and RUX were assessed in a commercial kinase potency screen performed by Carna Biosciences. ACVR1, BMPR1a, and TGFBR1 IC50s for MMB and RUX were generated at SelectScreen Biochemical Kinase Profiling Service (Thermo Fisher Scientific) using a 10-point dose titration of compound.