Genes that are upregulated in the Treg population B compared with population A
| Genes . | FDR q-value . | Normalized enrichment score . | Significant genes . |
|---|---|---|---|
| G2M checkpoint | <0.0001 | 2.0188198 | CASC5, NUSAP1, CENPE, TPX2, TOP2A, KIF11, BARD1, EZH2, SLC7A5, HN1, GINS2, CKS2, BUB1, SMC4, STIL, BRCA2, CHEK1, SAP30, E2F3, MKI67, CDKN2C, NEK2, KIF15, KPNA2, KIF23, ZAK, POLQ, WHSC1, TFDP1, UCK2, E2F2, CDKN3, CDC7, E2F1, AURKA, CDC20, EFNA5, KIF4A, EXO1, CDC25A, PRC1, KIF5B |
| Mitosis | 0.014934987 | 2.020 | NCAPH, NUSAP1, NDC80, CENPE, BUB1B, TPX2, KIF11, TTN, BUB1, NEK2, SMC4, PCBP4, PAM |
| M phase of mitotic cell cycle | 0.01755665 | 2.0006573 | NCAPH, NUSAP1, NDC80, CENPE, BUB1B, TPX2, KIF11, TTN, BUB1, NEK2, SMC4, PCBP4, PAM |
| IL2-STAT5 signaling | 0.02301426 | 1.5519865 | SYT11, CCR4, TNFRSF9, CST7, ADAM19, IL1R2, ANXA4, PHLDA1, SLC1A5, IL18R1, FGL2, TNFRSF18, TNFRSF4, GALM, CXCL10, BATF, SPP1, TNFSF10, PHTF2, CD86, AHNAK, IL10, LIF, TLR7, F2RL2, CD79B, CTLA4, FURIN, TNFRSF1B, CAPG, ALCAM, CSF1, CASP3, CSF2, MUC1, MYO1E RORA, ITGAV, PRNP, ICOS, UCK2, CYFIP1, SOCS1 |
| Immune response genes | 0.031976275 | 1.9183398 | IL7, CCR2, CCR8, CCR4, IL1R2, CCR6, CST7, CCL20, GZMA, CADM1, AIM2, CIITA, CCR5, CTSC, IL12A, NCF4, IL4, CCR9, GEM, IL32, TNFRSF4, LAX1, DEFB4A, FCGR3B, TLR7, CD74, APOA4, CCL5, APOBEC3G, CD79B, CTLA4 |
| Genes . | FDR q-value . | Normalized enrichment score . | Significant genes . |
|---|---|---|---|
| G2M checkpoint | <0.0001 | 2.0188198 | CASC5, NUSAP1, CENPE, TPX2, TOP2A, KIF11, BARD1, EZH2, SLC7A5, HN1, GINS2, CKS2, BUB1, SMC4, STIL, BRCA2, CHEK1, SAP30, E2F3, MKI67, CDKN2C, NEK2, KIF15, KPNA2, KIF23, ZAK, POLQ, WHSC1, TFDP1, UCK2, E2F2, CDKN3, CDC7, E2F1, AURKA, CDC20, EFNA5, KIF4A, EXO1, CDC25A, PRC1, KIF5B |
| Mitosis | 0.014934987 | 2.020 | NCAPH, NUSAP1, NDC80, CENPE, BUB1B, TPX2, KIF11, TTN, BUB1, NEK2, SMC4, PCBP4, PAM |
| M phase of mitotic cell cycle | 0.01755665 | 2.0006573 | NCAPH, NUSAP1, NDC80, CENPE, BUB1B, TPX2, KIF11, TTN, BUB1, NEK2, SMC4, PCBP4, PAM |
| IL2-STAT5 signaling | 0.02301426 | 1.5519865 | SYT11, CCR4, TNFRSF9, CST7, ADAM19, IL1R2, ANXA4, PHLDA1, SLC1A5, IL18R1, FGL2, TNFRSF18, TNFRSF4, GALM, CXCL10, BATF, SPP1, TNFSF10, PHTF2, CD86, AHNAK, IL10, LIF, TLR7, F2RL2, CD79B, CTLA4, FURIN, TNFRSF1B, CAPG, ALCAM, CSF1, CASP3, CSF2, MUC1, MYO1E RORA, ITGAV, PRNP, ICOS, UCK2, CYFIP1, SOCS1 |
| Immune response genes | 0.031976275 | 1.9183398 | IL7, CCR2, CCR8, CCR4, IL1R2, CCR6, CST7, CCL20, GZMA, CADM1, AIM2, CIITA, CCR5, CTSC, IL12A, NCF4, IL4, CCR9, GEM, IL32, TNFRSF4, LAX1, DEFB4A, FCGR3B, TLR7, CD74, APOA4, CCL5, APOBEC3G, CD79B, CTLA4 |
The most significant gene sets that are upregulated in the Treg B subpopulation compared with Treg A are listed. Leading-edge analysis revealed several genes that significantly contribute in each gene set and are enriched in Treg B compared with Treg A (marked as significant genes).