Frequency of VAV1 rearrangements in 148 PTCLs
| . | MP/RNA cases* . | Additional FISH cases . | Total . | P value† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n positive . | n tested . | % . | n positive . | n tested . | % . | n positive . | n tested . | % . | ||
| PTCL, NOS | 2 | 11 | 18 | 3 | 34 | 9 | 5 | 45 | 11 | 0.0153 |
| AITL | 0 | 0 | — | 0 | 36 | 0 | 0 | 36 | 0 | — |
| ALCL | 0 | 0 | — | 5 | 47 | 11 | 5 | 47 | 11 | 0.0175 |
| ALK+ | 0 | 0 | — | 1 | 18 | 6 | 1 | 18 | 6 | 0.2685 |
| ALK− | 0 | 0 | — | 4 | 25 | 16 | 4 | 25 | 16 | 0.0060 |
| Cutaneous | 0 | 0 | — | 0 | 4 | 0 | 0 | 4 | 0 | — |
| EATL | 0 | 0 | — | 0 | 5 | 0 | 0 | 5 | 0 | — |
| NKTL | 0 | 0 | — | 0 | 7 | 0 | 0 | 7 | 0 | — |
| CTCL | 0 | 0 | — | 0 | 6 | 0 | 0 | 6 | 0 | — |
| T-LGL | 0 | 0 | — | 0 | 2 | 0 | 0 | 2 | 0 | — |
| Total | 2 | 11 | 18 | 8 | 137 | 6 | 10 | 148 | 7 | — |
| . | MP/RNA cases* . | Additional FISH cases . | Total . | P value† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n positive . | n tested . | % . | n positive . | n tested . | % . | n positive . | n tested . | % . | ||
| PTCL, NOS | 2 | 11 | 18 | 3 | 34 | 9 | 5 | 45 | 11 | 0.0153 |
| AITL | 0 | 0 | — | 0 | 36 | 0 | 0 | 36 | 0 | — |
| ALCL | 0 | 0 | — | 5 | 47 | 11 | 5 | 47 | 11 | 0.0175 |
| ALK+ | 0 | 0 | — | 1 | 18 | 6 | 1 | 18 | 6 | 0.2685 |
| ALK− | 0 | 0 | — | 4 | 25 | 16 | 4 | 25 | 16 | 0.0060 |
| Cutaneous | 0 | 0 | — | 0 | 4 | 0 | 0 | 4 | 0 | — |
| EATL | 0 | 0 | — | 0 | 5 | 0 | 0 | 5 | 0 | — |
| NKTL | 0 | 0 | — | 0 | 7 | 0 | 0 | 7 | 0 | — |
| CTCL | 0 | 0 | — | 0 | 6 | 0 | 0 | 6 | 0 | — |
| T-LGL | 0 | 0 | — | 0 | 2 | 0 | 0 | 2 | 0 | — |
| Total | 2 | 11 | 18 | 8 | 137 | 6 | 10 | 148 | 7 | — |
Bold entries denote statistical significance, P < .05.
AITL, angioimmunoblastic T-cell lymphoma; ALK, anaplastic lymphoma kinase; CTCL, cutaneous T-cell lymphoma; EATL, enteropathy-associated T-cell lymphoma; NKTL, extranodal NK-/T-cell lymphoma, nasal type; T-LGL, T-cell large granular lymphocytic leukemia.
All cases also tested by FISH with 100% concordance.
Versus AITL, EATL, NKTL, CTCL, and T-LGL together.