Table 1. General characteristics and... | American Society of Hematology

Table 1.

General characteristics and prevalence of patients with NNAs in the study cohort

Characteristic	NNA negative		NNA positive		Crude OR	95% CI	P	Age-adjusted OR	95% CI	P
Characteristic	No.	%	No.	%	Crude OR	95% CI	P	Age-adjusted OR	95% CI	P
Age at screening (months)
Mean	17.5		27.4
Median	12		24
Maximum	67		59
Minimum	0		2
FVIII mutation
Null	173	93.5	12	6.5	1.0			1.0
Non-null	33	86.8	5	13.2	2.18	0.72-6.61	.167	2.29	0.74-7.10	.153
FVIII antigen levels, %
<1	195	92.9	15	7.1	1.0			1.0
≥1	21	87.5	3	12.5	1.86	0.50-6.94	.358	1.71	0.45-6.50	.434
Family history of inhibitors
No	69	95.8	3	4.2	1.0			1.0
Yes	21	91.3	2	8.7	2.19	0.34-14.00	.407	2.93	0.41-20.95	.284
Previous exposure to blood components (<5)
No	123	90.4	13	9.6	1.0			1.0
Yes	96	95.0	5	5.0	0.49	0.17-1.43	.193	0.41	0.14-1.22

Characteristic	NNA negative		NNA positive		Crude OR	95% CI	P	Age-adjusted OR	95% CI	P
Characteristic	No.	%	No.	%	Crude OR	95% CI	P	Age-adjusted OR	95% CI	P
Age at screening (months)
Mean	17.5		27.4
Median	12		24
Maximum	67		59
Minimum	0		2
FVIII mutation
Null	173	93.5	12	6.5	1.0			1.0
Non-null	33	86.8	5	13.2	2.18	0.72-6.61	.167	2.29	0.74-7.10	.153
FVIII antigen levels, %
<1	195	92.9	15	7.1	1.0			1.0
≥1	21	87.5	3	12.5	1.86	0.50-6.94	.358	1.71	0.45-6.50	.434
Family history of inhibitors
No	69	95.8	3	4.2	1.0			1.0
Yes	21	91.3	2	8.7	2.19	0.34-14.00	.407	2.93	0.41-20.95	.284
Previous exposure to blood components (<5)
No	123	90.4	13	9.6	1.0			1.0
Yes	96	95.0	5	5.0	0.49	0.17-1.43	.193	0.41	0.14-1.22

Crude and age-adjusted odds ratio (OR) for the presence of NNAs according to potential determinants.