Table 1.

RBC parameters in double-heterozygote mice reveal a significant increase in RBC number and hemoglobin with a decrease in reticulocyte count, MCV, MCH, and RDW in comparison with th3/+ mice

Hemoglobin (g/dL)RBCs (106 cells/μL)Reticulocytes (109 cells/L)RDW (%)MCV (fL)MCH (pg)
WT 15 ± 0.7 11 ± 0.4 313 ± 20 13 ± 0.3 43 ± 1.1 14 ± 0.2 
TfR1+/− 14 ± 0.3* 13 ± 0.3** 371 ± 33* 16 ± 0.5*** 36 ± 1.1*** 11 ± 0.2*** 
th3/+ 9 ± 0.2*** 10 ± 0.1* 1958 ± 128*** 36 ± 0.4*** 32 ± 1.2*** 9 ± 0.1*** 
Double-het 11 ± 0.2††† 13 ± 0.3††† 945 ± 39††† 24 ± 0.4††† 29 ± 0.5† 8 ± 0.1†† 
Hemoglobin (g/dL)RBCs (106 cells/μL)Reticulocytes (109 cells/L)RDW (%)MCV (fL)MCH (pg)
WT 15 ± 0.7 11 ± 0.4 313 ± 20 13 ± 0.3 43 ± 1.1 14 ± 0.2 
TfR1+/− 14 ± 0.3* 13 ± 0.3** 371 ± 33* 16 ± 0.5*** 36 ± 1.1*** 11 ± 0.2*** 
th3/+ 9 ± 0.2*** 10 ± 0.1* 1958 ± 128*** 36 ± 0.4*** 32 ± 1.2*** 9 ± 0.1*** 
Double-het 11 ± 0.2††† 13 ± 0.3††† 945 ± 39††† 24 ± 0.4††† 29 ± 0.5† 8 ± 0.1†† 

Data represent means ± standard errors of the mean; n = 8 mice per group.

Double-het, double-heterozygote mice.

*

P < .05; **P < .01; ***P < .001 vs WT.

†

P < .05; ††P < .01; †††P < .001 vs th3/+.

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