Characteristics and mortality rates for AML patients aged 65 years and older by hospital volume category (n = 7568)
| Variable . | Total . | Hospital volume category . | P* . | ||
|---|---|---|---|---|---|
| Low (<8 cases) . | High (8-15 cases) . | Very high (16-129 cases) . | |||
| No. of hospitals, % | 1895 (100) | 1706 (90.0) | 138 (7.3) | 51 (2.7) | |
| Median annual cases (IQR) | 2 (1-5) | 2 (1-4) | 10 (9-12) | 25 (19-34) | |
| No. of patients, % | 7568 (100) | 4450 (60.0) | 1499 (19.8) | 1529 (20.2) | |
| Patient characteristics, % | |||||
| Male | 56.7 | 55.9 | 57.0 | 58.7 | .16 |
| Race | .04 | ||||
| White | 88.8 | 88.6 | 90.6 | 87.7 | |
| Black | 6.6 | 6.5 | 6.2 | 7.4 | |
| Other | 4.6 | 4.9 | 3.1 | 5.0 | |
| Age category, y | <.001 | ||||
| 65-69 | 21.5 | 16.5 | 25.4 | 31.5 | |
| 70-79 | 42.7 | 40.3 | 43.6 | 47.3 | |
| 80+ | 36.6 | 43.1 | 31.0 | 21.3 | |
| Index admission type | <.001 | ||||
| Emergent | 58.7 | 65.5 | 52.8 | 44.2 | |
| Nonemergent | 41.3 | 34.5 | 47.2 | 55.8 | |
| Received chemotherapy at index admission | 26.1 | 14.5 | 36.4 | 50.3 | <.001 |
| Mean Charlson Comorbidity Index (SD) | 3.3 (1.5) | 3.4 (1.5) | 3.2 (1.4) | 3.0 (1.4) | <.001 |
| ≤2 | 35.5 | 34.7 | 41.8 | 49.3 | <.001 |
| 3-4 | 43.5 | 45.5 | 42.6 | 38.1 | |
| 5+ | 17.5 | 19.8 | 15.6 | 12.6 | |
| 30-day mortality | |||||
| Unadjusted | 36.0 | 42.1 | 33.8 | 19.8 | <.001 |
| Risk-adjusted | 31.4 | 32.0 | 32.1 | 28.1 | <.001 |
| 1-year mortality | |||||
| Unadjusted | 72.7 | 78.2 | 69.4 | 59.6 | <.001 |
| Risk-adjusted | 71.0 | 71.4 | 71.2 | 69.3 | <.001 |
| Variable . | Total . | Hospital volume category . | P* . | ||
|---|---|---|---|---|---|
| Low (<8 cases) . | High (8-15 cases) . | Very high (16-129 cases) . | |||
| No. of hospitals, % | 1895 (100) | 1706 (90.0) | 138 (7.3) | 51 (2.7) | |
| Median annual cases (IQR) | 2 (1-5) | 2 (1-4) | 10 (9-12) | 25 (19-34) | |
| No. of patients, % | 7568 (100) | 4450 (60.0) | 1499 (19.8) | 1529 (20.2) | |
| Patient characteristics, % | |||||
| Male | 56.7 | 55.9 | 57.0 | 58.7 | .16 |
| Race | .04 | ||||
| White | 88.8 | 88.6 | 90.6 | 87.7 | |
| Black | 6.6 | 6.5 | 6.2 | 7.4 | |
| Other | 4.6 | 4.9 | 3.1 | 5.0 | |
| Age category, y | <.001 | ||||
| 65-69 | 21.5 | 16.5 | 25.4 | 31.5 | |
| 70-79 | 42.7 | 40.3 | 43.6 | 47.3 | |
| 80+ | 36.6 | 43.1 | 31.0 | 21.3 | |
| Index admission type | <.001 | ||||
| Emergent | 58.7 | 65.5 | 52.8 | 44.2 | |
| Nonemergent | 41.3 | 34.5 | 47.2 | 55.8 | |
| Received chemotherapy at index admission | 26.1 | 14.5 | 36.4 | 50.3 | <.001 |
| Mean Charlson Comorbidity Index (SD) | 3.3 (1.5) | 3.4 (1.5) | 3.2 (1.4) | 3.0 (1.4) | <.001 |
| ≤2 | 35.5 | 34.7 | 41.8 | 49.3 | <.001 |
| 3-4 | 43.5 | 45.5 | 42.6 | 38.1 | |
| 5+ | 17.5 | 19.8 | 15.6 | 12.6 | |
| 30-day mortality | |||||
| Unadjusted | 36.0 | 42.1 | 33.8 | 19.8 | <.001 |
| Risk-adjusted | 31.4 | 32.0 | 32.1 | 28.1 | <.001 |
| 1-year mortality | |||||
| Unadjusted | 72.7 | 78.2 | 69.4 | 59.6 | <.001 |
| Risk-adjusted | 71.0 | 71.4 | 71.2 | 69.3 | <.001 |
IQR, interquartile range; SD, standard deviation.
P values based on χ2 tests and Student t tests for categorical and continuous variables, respectively.