95% CI, 95% confidence interval; ECOG, Eastern Cooperative Oncology Group; MRC, Medical Research Council; ITD, internal tandem duplication.

629 patients were included in the multivariate model, whereas 35 patients (5%) were excluded because of missing data. Gene mutations were included in the multivariate model if they were detected in at least 20 patients and had a univariate P value for OS, not adjusted for multiple comparisons, of ≤.10. The model was stratified for trial arm. No variable selection or elimination technique was applied, and all variables were retained in the final model. Tests for interaction with age group (<60 y vs ≥60 y) were performed for each variable.

*The P value for the interaction between DNMT3A mutation status and age group was .018.

†The P value for the interaction between RUNX1 mutation status and age group was .015.