Transgenic murine hematologic indices
| . | Mean ± SD . | ||
|---|---|---|---|
| Wild-type . | w/ human Hb site . | w/o Hb site . | |
| n | 8 | 12 | 15 |
| (4 female; 4 male) | (6 female; 6 male) | (7 female; 8 male) | |
| RBC, ×1012/L | 10.67 ± 0.64 | 10.58 ± 0.25 | 8.91 ± 1.36*† |
| Hb, g/L | 160.3 ± 2.8 | 159.8 ± 5.1 | 153.7 ± 6.1*† |
| Hematocrit, % | 47.34 ± 2.04 | 44.63 ± 1.40* | 44.06 ± 2.46* |
| MCH | 15.33 ± 0.39 | 15.36 ± 0.42 | 16.77 ± 0.80* |
| MCV, fL | 42.18 ± 1.69 | 42.12 ± 0.48 | 47.68 ± 2.27* |
| Reticulocytes, % | 4.35 ± 0.29 | 4.62 ± 0.53 | 5.14 ± 0.78 |
| WBC, ×109/L | 7.00 ± 3.36 | 7.68 ± 0.93* | 11.86 ± 3.46*† |
| Platelet, ×109/L | 899.8 ± 110 | 850.0 ± 104 | 805.4 ± 111 |
| n | 5 | 4 | 5 |
| Total cells in marrow, ×107 | 7.30 ± 0.62 | 8.38 ± 1.84 | 7.78 ± 1.65 |
| Ter119+ cells in marrow, ×107 | 2.87 ± 0.39 | 3.43 ± 1.15 | 3.63 ± 1.07 |
| Ter119+ cells in marrow (%) | 39.3 ± 4.2 | 40.8 ± 10.5 | 46.6 ± 8.1*† |
| Total cells in spleen, ×107 | 30.14 ± 5.81 | 34.35 ± 7.37 | 60.61 ± 9.38*† |
| Ter119+ cells in spleen, ×107 | 14.88 ± 2.83 | 19.98 ± 5.55 | 50.49 ± 12.95*† |
| Ter119+ cells in spleen, % | 49.9 ± 3.1 | 57.8 ± 6.4* | 82.4 ± 12.4*† |
| Spleen weight, g | 0.11 ± 0.01 | 0.13 ± 0.04 | 0.24 ± 0.04*† |
| . | Mean ± SD . | ||
|---|---|---|---|
| Wild-type . | w/ human Hb site . | w/o Hb site . | |
| n | 8 | 12 | 15 |
| (4 female; 4 male) | (6 female; 6 male) | (7 female; 8 male) | |
| RBC, ×1012/L | 10.67 ± 0.64 | 10.58 ± 0.25 | 8.91 ± 1.36*† |
| Hb, g/L | 160.3 ± 2.8 | 159.8 ± 5.1 | 153.7 ± 6.1*† |
| Hematocrit, % | 47.34 ± 2.04 | 44.63 ± 1.40* | 44.06 ± 2.46* |
| MCH | 15.33 ± 0.39 | 15.36 ± 0.42 | 16.77 ± 0.80* |
| MCV, fL | 42.18 ± 1.69 | 42.12 ± 0.48 | 47.68 ± 2.27* |
| Reticulocytes, % | 4.35 ± 0.29 | 4.62 ± 0.53 | 5.14 ± 0.78 |
| WBC, ×109/L | 7.00 ± 3.36 | 7.68 ± 0.93* | 11.86 ± 3.46*† |
| Platelet, ×109/L | 899.8 ± 110 | 850.0 ± 104 | 805.4 ± 111 |
| n | 5 | 4 | 5 |
| Total cells in marrow, ×107 | 7.30 ± 0.62 | 8.38 ± 1.84 | 7.78 ± 1.65 |
| Ter119+ cells in marrow, ×107 | 2.87 ± 0.39 | 3.43 ± 1.15 | 3.63 ± 1.07 |
| Ter119+ cells in marrow (%) | 39.3 ± 4.2 | 40.8 ± 10.5 | 46.6 ± 8.1*† |
| Total cells in spleen, ×107 | 30.14 ± 5.81 | 34.35 ± 7.37 | 60.61 ± 9.38*† |
| Ter119+ cells in spleen, ×107 | 14.88 ± 2.83 | 19.98 ± 5.55 | 50.49 ± 12.95*† |
| Ter119+ cells in spleen, % | 49.9 ± 3.1 | 57.8 ± 6.4* | 82.4 ± 12.4*† |
| Spleen weight, g | 0.11 ± 0.01 | 0.13 ± 0.04 | 0.24 ± 0.04*† |