Items not applicable to each study as well as those assessed adequate are coded 1. Details of scoring are provided in Moher et al.⁸  The designation of 0 corresponds to the absence and 1 corresponds to the presence of a potential deficiency. The following score/domain correspondence was used: 1a, identification as RCT in the title; 1b, structured summary of trial design, methods, results, and conclusions; 2a, background and rationale; 2b, objectives and/or hypotheses; 3a, design including allocation ratio; 3b, important changes to methods after trial commencement; 4a, eligibility criteria; 4b, settings and locations; 5, interventions; 6a, prespecified outcomes; 6b, changes to outcomes after trial commencement; 7a, sample size determination; 7b, interim analyses, if applicable; 8a, random allocation sequence generation; 8b, randomization type; 9, allocation concealment; 10, who generated the random allocation sequence, who enrolled participants, and who assigned them to interventions; 11a, blinding; 11b, similarity of interventions, if applicable; 12a, statistical methods for primary and secondary end points; 12b, methods for additional analyses; 13a, flow diagram or equivalent; 13b, losses and/or exclusions after randomization, with reasons; 14a, recruitment and/or follow-up dates; 14b, why the trial ended or was stopped, if applicable; 15, baseline demographics and clinical characteristics of each group; 16, number analyzed in each group and whether analysis was intention to treat; 17a, results in each group, effect size and its precision for each outcome; 17b, absolute and relative effect size recommended for binary outcomes; recommended; 18, results of other analyses; 19, harms and unintended effects in each group; 20, limitations, including biases and imprecisions; 21, generalizability; 22, consistency of interpretation and results, balancing benefits and harms, other relevant evidence; 23, registration number and name of registry; 24, where the full protocol can be accessed, if available; 25, funding and its role.