Adverse events experienced by at least 2 subjects during the trial
| Event . | Any grade . | Grade 3 or 4 . |
|---|---|---|
| ALT increase | 19 (79%) | 13 (54%) |
| AST increase | 19 (79%) | 10 (42%) |
| Colitis/diarrhea/enteritis | 11 (46%) | 4 (17%) |
| Blood bilirubin level increase | 10 (42%) | 1 (4%) |
| Rash | 8 (33%) | 3 (13%) |
| Alkaline phosphatase level increase | 8 (33%) | 0 (0%) |
| Nausea/vomiting | 8 (33%) | 0 (0%) |
| Abdominal pain | 7 (29%) | 0 (0%) |
| Constipation | 7 (29%) | 0 (0%) |
| Myalgia | 5 (21%) | 1 (4%) |
| Arthralgia | 5 (21%) | 0 (0%) |
| Cough | 5 (21%) | 0 (0%) |
| Edema | 5 (21%) | 0 (0%) |
| Chills | 4 (17%) | 0 (0%) |
| Dysgeusia | 4 (17%) | 0 (0%) |
| Night sweats | 4 (17%) | 0 (0%) |
| Insomnia | 4 (17%) | 0 (0%) |
| Weight loss | 4 (17%) | 0 (0%) |
| Lung infection | 3 (13%) | 3 (13%) |
| Hyperglycemia | 3 (13%) | 2 (8%) |
| Pneumonitis | 3 (13%) | 2 (8%) |
| Hypotension | 3 (13%) | 1 (4%) |
| Infusion-related reaction | 3 (13%) | 1 (4%) |
| Anorexia | 3 (13%) | 0 (0%) |
| Dizziness | 3 (13%) | 0 (0%) |
| Dry mouth | 3 (13%) | 0 (0%) |
| Dry skin | 3 (13%) | 0 (0%) |
| Dyspnea | 3 (13%) | 0 (0%) |
| GERD | 3 (13%) | 0 (0%) |
| Hyponatremia | 2 (8%) | 2 (8%) |
| Anemia | 2 (8%) | 1 (4%) |
| Hypertension | 2 (8%) | 1 (4%) |
| Oral mucositis | 2 (8%) | 1 (4%) |
| Alopecia | 2 (8%) | 0 (0%) |
| Back pain | 2 (8%) | 0 (0%) |
| Bronchial infection | 2 (8%) | 0 (0%) |
| Depression | 2 (8%) | 0 (0%) |
| Nasal congestion | 2 (8%) | 0 (0%) |
| Platelet count decreased | 2 (8%) | 0 (0%) |
| Polyuria | 2 (8%) | 0 (0%) |
| White blood cell count decreased | 2 (8%) | 0 (0%) |
| Event . | Any grade . | Grade 3 or 4 . |
|---|---|---|
| ALT increase | 19 (79%) | 13 (54%) |
| AST increase | 19 (79%) | 10 (42%) |
| Colitis/diarrhea/enteritis | 11 (46%) | 4 (17%) |
| Blood bilirubin level increase | 10 (42%) | 1 (4%) |
| Rash | 8 (33%) | 3 (13%) |
| Alkaline phosphatase level increase | 8 (33%) | 0 (0%) |
| Nausea/vomiting | 8 (33%) | 0 (0%) |
| Abdominal pain | 7 (29%) | 0 (0%) |
| Constipation | 7 (29%) | 0 (0%) |
| Myalgia | 5 (21%) | 1 (4%) |
| Arthralgia | 5 (21%) | 0 (0%) |
| Cough | 5 (21%) | 0 (0%) |
| Edema | 5 (21%) | 0 (0%) |
| Chills | 4 (17%) | 0 (0%) |
| Dysgeusia | 4 (17%) | 0 (0%) |
| Night sweats | 4 (17%) | 0 (0%) |
| Insomnia | 4 (17%) | 0 (0%) |
| Weight loss | 4 (17%) | 0 (0%) |
| Lung infection | 3 (13%) | 3 (13%) |
| Hyperglycemia | 3 (13%) | 2 (8%) |
| Pneumonitis | 3 (13%) | 2 (8%) |
| Hypotension | 3 (13%) | 1 (4%) |
| Infusion-related reaction | 3 (13%) | 1 (4%) |
| Anorexia | 3 (13%) | 0 (0%) |
| Dizziness | 3 (13%) | 0 (0%) |
| Dry mouth | 3 (13%) | 0 (0%) |
| Dry skin | 3 (13%) | 0 (0%) |
| Dyspnea | 3 (13%) | 0 (0%) |
| GERD | 3 (13%) | 0 (0%) |
| Hyponatremia | 2 (8%) | 2 (8%) |
| Anemia | 2 (8%) | 1 (4%) |
| Hypertension | 2 (8%) | 1 (4%) |
| Oral mucositis | 2 (8%) | 1 (4%) |
| Alopecia | 2 (8%) | 0 (0%) |
| Back pain | 2 (8%) | 0 (0%) |
| Bronchial infection | 2 (8%) | 0 (0%) |
| Depression | 2 (8%) | 0 (0%) |
| Nasal congestion | 2 (8%) | 0 (0%) |
| Platelet count decreased | 2 (8%) | 0 (0%) |
| Polyuria | 2 (8%) | 0 (0%) |
| White blood cell count decreased | 2 (8%) | 0 (0%) |