Mouse models that recapitulate somatic gene mutations and/or portions of CMML
| Gene . | Incidence . | Het/homo . | KO/mutation . | Cre-driver . | Cytopenias . | Monocytosis . | Dysplasia . | Splenomegaly . | Penetrance . | Other phenotypes . | PMID . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ASXL1 | 40-45 | Homo | KO | MX1/VAV | Yes | No | Yes | No | 100% | None | 24218140 |
| SRSF2 | 30-45 | Het | Mutation | MX1 | Yes | No | Yes | No | 100% | None | 25965569 |
| TET2 | 40-60 | Homo | KO | VAV | No | Yes | Yes | Yes | 70% | None | 21723200 |
| RUNX1 | 15-20 | Homo | KO | MX1 | Yes | No | Yes | X | 100% | None | 14966519 |
| CBL | 15-20 | Homo | KO | Const | No | X | X | Yes | X | X | 19620960 |
| KRAS | 10-15 | Het | Mutation | MX1 | Yes | Yes | No | Yes | 100% | None | 14699048 |
| NRAS | 10-15 | Het | Mutation | MX1 | Yes | Yes | Yes | Yes | Incomplete | HS, LPD | 21163920 |
| JAK2 | 7-10 | Het/homo | Mutation | MX1 | No | No | No | Yes | 100% | None | 20197548 |
| EZH2 | 10 | Homo | KO | MX1 | No | No | No | Yes | 100% | None | 22431509 |
| NF1 | <5% | Het | KO | MX1 | No | Yes | No | Yes | 100% | None | 14982883 |
| TAK1 | 0 | Het/homo | KO | LsyM | X | Yes | No | Yes | Incomplete | AML | 23251462 |
| XIST | 0 | Het/homo | KO | VAV | Yes | Yes | Yes | Yes | Incomplete | HS, vasculitis | 23415223 |
| NCSTN | 0 | Homo | KO | MX1/VAV | X | Yes | Yes | Yes | 100% | None | 21562564 |
| CREBBP | 0 | Het | KO | Const | Yes | X | Yes | Yes | 100% | None | 22198154 |
| NR4A | 0 | Het/homo | KO | Const | Yes | No | Yes | Yes | Incomplete | AML | 21205929 |
| Gene . | Incidence . | Het/homo . | KO/mutation . | Cre-driver . | Cytopenias . | Monocytosis . | Dysplasia . | Splenomegaly . | Penetrance . | Other phenotypes . | PMID . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ASXL1 | 40-45 | Homo | KO | MX1/VAV | Yes | No | Yes | No | 100% | None | 24218140 |
| SRSF2 | 30-45 | Het | Mutation | MX1 | Yes | No | Yes | No | 100% | None | 25965569 |
| TET2 | 40-60 | Homo | KO | VAV | No | Yes | Yes | Yes | 70% | None | 21723200 |
| RUNX1 | 15-20 | Homo | KO | MX1 | Yes | No | Yes | X | 100% | None | 14966519 |
| CBL | 15-20 | Homo | KO | Const | No | X | X | Yes | X | X | 19620960 |
| KRAS | 10-15 | Het | Mutation | MX1 | Yes | Yes | No | Yes | 100% | None | 14699048 |
| NRAS | 10-15 | Het | Mutation | MX1 | Yes | Yes | Yes | Yes | Incomplete | HS, LPD | 21163920 |
| JAK2 | 7-10 | Het/homo | Mutation | MX1 | No | No | No | Yes | 100% | None | 20197548 |
| EZH2 | 10 | Homo | KO | MX1 | No | No | No | Yes | 100% | None | 22431509 |
| NF1 | <5% | Het | KO | MX1 | No | Yes | No | Yes | 100% | None | 14982883 |
| TAK1 | 0 | Het/homo | KO | LsyM | X | Yes | No | Yes | Incomplete | AML | 23251462 |
| XIST | 0 | Het/homo | KO | VAV | Yes | Yes | Yes | Yes | Incomplete | HS, vasculitis | 23415223 |
| NCSTN | 0 | Homo | KO | MX1/VAV | X | Yes | Yes | Yes | 100% | None | 21562564 |
| CREBBP | 0 | Het | KO | Const | Yes | X | Yes | Yes | 100% | None | 22198154 |
| NR4A | 0 | Het/homo | KO | Const | Yes | No | Yes | Yes | Incomplete | AML | 21205929 |
Mouse models generated in a hematopoietic tissue-specific manner were favored in this table when available. Incidence of gene mutations derived for previous studies.5-10
Const, constitutional; Cre-driver, used transgenic mouse system; het, heterozygous; homo, homozygous; HS, histiocytic sarcoma; incomplete, exact penetrance not reported or other phenotypes observed; KO, knockout; LPD, lymphoproliferative disorder; PMID, unique identifier number used in PubMed; X, not reported.