Nonhematologic adverse events
| . | All grades . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Rash | 82% | 41% | 5% | 36% | 0% |
| Diarrhea | 64% | 50% | 9% | 5% | 0% |
| Fatigue | 59% | 45% | 14% | 0% | 0% |
| Infusion-related reaction | 37% | 14% | 23% | 0% | 0% |
| Nausea | 32% | 32% | 0% | 0% | 0% |
| Infection | 28% | 5% | 23% | 0% | 0% |
| Neoplasms | 23% | 0% | 5% | 18% | 0% |
| Arthralgia | 19% | 14% | 0% | 5% | 0% |
| Hyperbilirubinemia | 19% | 14% | 5% | 0% | 0% |
| ALT increased | 19% | 14% | 5% | 0% | 0% |
| AST increased | 18% | 18% | 0% | 0% | 0% |
| Headache | 18% | 18% | 0% | 0% | 0% |
| Constipation | 14% | 14% | 0% | 0% | 0% |
| Edema | 14% | 9% | 5% | 0% | 0% |
| Fever | 14% | 5% | 9% | 0% | 0% |
| Creatinine increased | 9% | 9% | 0% | 0% | 0% |
| Neuropathy | 9% | 9% | 0% | 0% | 0% |
| Hyperuricemia | 9% | 9% | 0% | 0% | 0% |
| Atrial flutter | 5% | 0% | 0% | 5% | 0% |
| Periorbital edema | 5% | 0% | 0% | 5% | 0% |
| Febrile neutropenia | 5% | 0% | 0% | 5% | 0% |
| . | All grades . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Rash | 82% | 41% | 5% | 36% | 0% |
| Diarrhea | 64% | 50% | 9% | 5% | 0% |
| Fatigue | 59% | 45% | 14% | 0% | 0% |
| Infusion-related reaction | 37% | 14% | 23% | 0% | 0% |
| Nausea | 32% | 32% | 0% | 0% | 0% |
| Infection | 28% | 5% | 23% | 0% | 0% |
| Neoplasms | 23% | 0% | 5% | 18% | 0% |
| Arthralgia | 19% | 14% | 0% | 5% | 0% |
| Hyperbilirubinemia | 19% | 14% | 5% | 0% | 0% |
| ALT increased | 19% | 14% | 5% | 0% | 0% |
| AST increased | 18% | 18% | 0% | 0% | 0% |
| Headache | 18% | 18% | 0% | 0% | 0% |
| Constipation | 14% | 14% | 0% | 0% | 0% |
| Edema | 14% | 9% | 5% | 0% | 0% |
| Fever | 14% | 5% | 9% | 0% | 0% |
| Creatinine increased | 9% | 9% | 0% | 0% | 0% |
| Neuropathy | 9% | 9% | 0% | 0% | 0% |
| Hyperuricemia | 9% | 9% | 0% | 0% | 0% |
| Atrial flutter | 5% | 0% | 0% | 5% | 0% |
| Periorbital edema | 5% | 0% | 0% | 5% | 0% |
| Febrile neutropenia | 5% | 0% | 0% | 5% | 0% |
ALT, alanine transaminase; AST, aspartate transaminase.