The influence of DIC parameters on the occurrence of a thrombotic event (Cox regression)
| . | Younger (test cohort) . | Elderly (validation cohort) . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | VTE . | AT . | No event . | HR (95% CI) . | HR (95% CI) . | ||||
| Risk factor . | . | . | . | VTE . | AT . | Any event . | VTE . | AT . | Any event . |
| Total | 9 | 9 | 252 | ||||||
| PT | P = .076 | P = .21 | P = .020 | P = .092 | P = .39 | P = .092 | |||
| <16.3 s, n | 6 | 7 | 232 | ||||||
| ≤19.3 s, n | 2 | 1 | 17 | 4.38 (0.88-21.69) | 1.88 (0.23-15.26) | 3.03 (0.86-10.64) | 10.31 (1.45-73.40) | 1.58 (0.19-13.13) | 4.39 (1.13-16.98) |
| >19.3 s, n | 1 | 1 | 3 | 12.22 (1.46-102.10) | 11.28 (1.37-92.70) | 11.71 (2.63-52.17) | na | 5.91 (0.71-49.37) | 5.10 (0.62-41.63) |
| D-dimer | P = .002 | P = .24 | P < .001 | P = .013 | P = .046 | P = .01 | |||
| ≤0.5 mg/L, n | 1 | 3 | 134 | ||||||
| 0.5-4.0 mg/L, n | 4 | 4 | 98 | 5.58 (0.62-49.97) | 1.86 (0.42-8.33) | 2.79 (0.84-9.28) | na | 1.41 (0.24-8.47) | 0.73 (0.16-3.24) |
| >4.0 mg/L, n | 4 | 2 | 15 | 32.05 (3.58-286.83) | 5.35 (0.89-32.03) | 12.03 (3.39-42.64) | 7.66 (1.07-54.80) | 9.52 (1.59-57.12) | 7.82 (1.95-31.38) |
| Platelet count 109/L | P = .72 | P = .031 | P = .12 | P = .25 | P = .15 | P = .31 | |||
| <50, n | 5 | 5 | 108 | ||||||
| 51-100, n | 2 | 0 | 81 | 0.54 (0.10-2.78) | 0.00 (0.00-) | 0.27 (0.06-1.23) | na | 6.67 (0.74-59.79) | 3.54 (0.65-19.39) |
| >100, n | 2 | 4 | 63 | 0.66 (0.13-3.38) | 1.32 (0.35-4.92) | 0.99 (0.36-2.71) | 2.66 (0.28-25.61) | 2.92 (0.26-24.30) | 2.22 (0.43-11.46) |
| Fibrinogen score | P = .079 | P = .031 | P = .12 | ||||||
| >1 | 8 | 9 | 250 | ||||||
| <1 | 1 | 0 | 2 | 12.38 (1.54-99.18) | 0.00 (0.00) | 5.79 (0.77-43.56) | na | na | na |
| α-2-Antiplasmin | P = .033 | P = .45 | P = .029 | ||||||
| >0.8 IU/mL, n | 4 | 3 | 128 | ||||||
| ≤0.8 IU/mL, n | 3 | 1 | 15 | 5.99 (1.34-26.76) | 2.59 (0.27-24.91) | 4.52 (1.32-15.44) | na | na | na |
| Antithrombin | P = .13 | P = .093 | P = .025 | P = .92 | P = .46 | P = .7 | |||
| >0.8 IU/mL, n | 6 | 5 | 212 | ||||||
| ≤0.8 IU/mL, n | 3 | 3 | 32 | 3.16 (0.79-12.62) | 3.80 (0.91-15.90) | 3.45 (1.27-9.32) | 1.12 (0.12-10.75) | 0.48 (0.06-3.92) | 0.74 (0.16-3.43) |
| DIC score | P = .025 | P = .16 | P = .009 | P = .077 | P = .0016 | P = .0013 | |||
| <5, n | 6 | 7 | 234 | ||||||
| ≥5, n | 3 | 2 | 18 | 6.21 (1.55-24.85) | 3.57 (0.74-17.19) | 4.79 (1.71-13.45) | 16.99 (1.06-272.58) | 19.15 (3.86-95.11) | 11.08 (3.23-38.06) |
| . | Younger (test cohort) . | Elderly (validation cohort) . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| . | VTE . | AT . | No event . | HR (95% CI) . | HR (95% CI) . | ||||
| Risk factor . | . | . | . | VTE . | AT . | Any event . | VTE . | AT . | Any event . |
| Total | 9 | 9 | 252 | ||||||
| PT | P = .076 | P = .21 | P = .020 | P = .092 | P = .39 | P = .092 | |||
| <16.3 s, n | 6 | 7 | 232 | ||||||
| ≤19.3 s, n | 2 | 1 | 17 | 4.38 (0.88-21.69) | 1.88 (0.23-15.26) | 3.03 (0.86-10.64) | 10.31 (1.45-73.40) | 1.58 (0.19-13.13) | 4.39 (1.13-16.98) |
| >19.3 s, n | 1 | 1 | 3 | 12.22 (1.46-102.10) | 11.28 (1.37-92.70) | 11.71 (2.63-52.17) | na | 5.91 (0.71-49.37) | 5.10 (0.62-41.63) |
| D-dimer | P = .002 | P = .24 | P < .001 | P = .013 | P = .046 | P = .01 | |||
| ≤0.5 mg/L, n | 1 | 3 | 134 | ||||||
| 0.5-4.0 mg/L, n | 4 | 4 | 98 | 5.58 (0.62-49.97) | 1.86 (0.42-8.33) | 2.79 (0.84-9.28) | na | 1.41 (0.24-8.47) | 0.73 (0.16-3.24) |
| >4.0 mg/L, n | 4 | 2 | 15 | 32.05 (3.58-286.83) | 5.35 (0.89-32.03) | 12.03 (3.39-42.64) | 7.66 (1.07-54.80) | 9.52 (1.59-57.12) | 7.82 (1.95-31.38) |
| Platelet count 109/L | P = .72 | P = .031 | P = .12 | P = .25 | P = .15 | P = .31 | |||
| <50, n | 5 | 5 | 108 | ||||||
| 51-100, n | 2 | 0 | 81 | 0.54 (0.10-2.78) | 0.00 (0.00-) | 0.27 (0.06-1.23) | na | 6.67 (0.74-59.79) | 3.54 (0.65-19.39) |
| >100, n | 2 | 4 | 63 | 0.66 (0.13-3.38) | 1.32 (0.35-4.92) | 0.99 (0.36-2.71) | 2.66 (0.28-25.61) | 2.92 (0.26-24.30) | 2.22 (0.43-11.46) |
| Fibrinogen score | P = .079 | P = .031 | P = .12 | ||||||
| >1 | 8 | 9 | 250 | ||||||
| <1 | 1 | 0 | 2 | 12.38 (1.54-99.18) | 0.00 (0.00) | 5.79 (0.77-43.56) | na | na | na |
| α-2-Antiplasmin | P = .033 | P = .45 | P = .029 | ||||||
| >0.8 IU/mL, n | 4 | 3 | 128 | ||||||
| ≤0.8 IU/mL, n | 3 | 1 | 15 | 5.99 (1.34-26.76) | 2.59 (0.27-24.91) | 4.52 (1.32-15.44) | na | na | na |
| Antithrombin | P = .13 | P = .093 | P = .025 | P = .92 | P = .46 | P = .7 | |||
| >0.8 IU/mL, n | 6 | 5 | 212 | ||||||
| ≤0.8 IU/mL, n | 3 | 3 | 32 | 3.16 (0.79-12.62) | 3.80 (0.91-15.90) | 3.45 (1.27-9.32) | 1.12 (0.12-10.75) | 0.48 (0.06-3.92) | 0.74 (0.16-3.43) |
| DIC score | P = .025 | P = .16 | P = .009 | P = .077 | P = .0016 | P = .0013 | |||
| <5, n | 6 | 7 | 234 | ||||||
| ≥5, n | 3 | 2 | 18 | 6.21 (1.55-24.85) | 3.57 (0.74-17.19) | 4.79 (1.71-13.45) | 16.99 (1.06-272.58) | 19.15 (3.86-95.11) | 11.08 (3.23-38.06) |
na, not applicable.