Characteristics of 270 younger and 126 elderly AML patients with and without DIC at diagnosis
| . | YOUNGER (test cohort) . | . | ELDERLY (validation cohort) . | . | ||
|---|---|---|---|---|---|---|
| . | DIC n = 23 . | No DIC n = 247 . | P value . | DIC n = 8 . | No DIC n = 118 . | P value . |
| Male sex, n (%) | 11 (48) | 129 (52) | .828 | 5 (63) | 58 (49) | .717 |
| Mean age at enrollment, y (range) | 45 (20-61) | 47 (18-65) | 69 (65-74) | 67 (61-77) | ||
| FAB | .003 | .069 | ||||
| M0, n (%) | 2 (9) | 11 (4) | 1 (13) | 2 (2) | ||
| M1, n (%) | 3 (13) | 38 (15) | 3 (38) | 20 (17) | ||
| M2, n (%) | 3 (13) | 72 (29) | 0 | 43 (36) | ||
| M4, n (%) | 2 (9) | 30 (12) | 2 (25) | 11 (9) | ||
| M5, n (%) | 12 (52) | 34 (14) | 1 (13) | 10 (8) | ||
| M6, n (%) | 0 | 5 (2) | 0 | 5 (4) | ||
| RAEB, n (%) | 0 | 13 (5) | 0 | 8 (7) | ||
| RAEB-t, n (%) | 0 | 35 (14) | 1 (13) | 18 (15) | ||
| Unknown, n (%) | 1 (4) | 9 (4) | 0 | 1 (1) | ||
| Karyotype | .245 | .32 | ||||
| t (8;21), n (%) | 1 (4) | 8 (3) | 0 | 5 (4) | ||
| inv (16), n (%) | 2 (9) | 13 (5) | 1 (13) | 4 (3) | ||
| CN –X-Y, n (%) | 8 (35) | 133 (54) | 5 (63) | 50 (42) | ||
| CA Rest, n (%) | 7 (30) | 62 (25) | 1 (13) | 44 (37) | ||
| MK, n (%) | 5 (22) | 29 (12) | 1 (13) | 12 (10) | ||
| Unknown, n (%) | 0 | 2 (1) | 0 | 3 (3) | ||
| Leukocytes 109/L, mean; range | 64.1 (1.0-215) | 23.9 (0.5-232) | .005 | 65.7 (1.2-144) | 23.6 (0.7-200) | .04 |
| Platelets 109/L, mean; range | 36 (6-69) | 89 (6-701) | .000 | 34.8 (6-59) | 86.6 (9-449) | .025 |
| Blasts in bone marrow, mean; range, % | 74 (5-97) | 50 (2-95) | .000 | 73 (18-95) | 46 (2-95) | .009 |
| Event group, n (%) | .015 | .002 | ||||
| Venous thrombosis | 3 (13) | 6 (2) | 1 (13) | 2 (2) | ||
| Arterial thrombosis | 2 (9) | 7 (3) | 3 (38) | 5 (4) | ||
| Major bleeding, n (%) | 1 (4) | 10 (4) | 1.00 | 0 | 16 (13) | |
| . | YOUNGER (test cohort) . | . | ELDERLY (validation cohort) . | . | ||
|---|---|---|---|---|---|---|
| . | DIC n = 23 . | No DIC n = 247 . | P value . | DIC n = 8 . | No DIC n = 118 . | P value . |
| Male sex, n (%) | 11 (48) | 129 (52) | .828 | 5 (63) | 58 (49) | .717 |
| Mean age at enrollment, y (range) | 45 (20-61) | 47 (18-65) | 69 (65-74) | 67 (61-77) | ||
| FAB | .003 | .069 | ||||
| M0, n (%) | 2 (9) | 11 (4) | 1 (13) | 2 (2) | ||
| M1, n (%) | 3 (13) | 38 (15) | 3 (38) | 20 (17) | ||
| M2, n (%) | 3 (13) | 72 (29) | 0 | 43 (36) | ||
| M4, n (%) | 2 (9) | 30 (12) | 2 (25) | 11 (9) | ||
| M5, n (%) | 12 (52) | 34 (14) | 1 (13) | 10 (8) | ||
| M6, n (%) | 0 | 5 (2) | 0 | 5 (4) | ||
| RAEB, n (%) | 0 | 13 (5) | 0 | 8 (7) | ||
| RAEB-t, n (%) | 0 | 35 (14) | 1 (13) | 18 (15) | ||
| Unknown, n (%) | 1 (4) | 9 (4) | 0 | 1 (1) | ||
| Karyotype | .245 | .32 | ||||
| t (8;21), n (%) | 1 (4) | 8 (3) | 0 | 5 (4) | ||
| inv (16), n (%) | 2 (9) | 13 (5) | 1 (13) | 4 (3) | ||
| CN –X-Y, n (%) | 8 (35) | 133 (54) | 5 (63) | 50 (42) | ||
| CA Rest, n (%) | 7 (30) | 62 (25) | 1 (13) | 44 (37) | ||
| MK, n (%) | 5 (22) | 29 (12) | 1 (13) | 12 (10) | ||
| Unknown, n (%) | 0 | 2 (1) | 0 | 3 (3) | ||
| Leukocytes 109/L, mean; range | 64.1 (1.0-215) | 23.9 (0.5-232) | .005 | 65.7 (1.2-144) | 23.6 (0.7-200) | .04 |
| Platelets 109/L, mean; range | 36 (6-69) | 89 (6-701) | .000 | 34.8 (6-59) | 86.6 (9-449) | .025 |
| Blasts in bone marrow, mean; range, % | 74 (5-97) | 50 (2-95) | .000 | 73 (18-95) | 46 (2-95) | .009 |
| Event group, n (%) | .015 | .002 | ||||
| Venous thrombosis | 3 (13) | 6 (2) | 1 (13) | 2 (2) | ||
| Arterial thrombosis | 2 (9) | 7 (3) | 3 (38) | 5 (4) | ||
| Major bleeding, n (%) | 1 (4) | 10 (4) | 1.00 | 0 | 16 (13) | |