Potential clearance receptors for FVIII and VWF
| Receptor* . | FVIII† . | Clearance?‡ . | VWF† . | Clearance?‡ . |
|---|---|---|---|---|
| LRP1 | Yes | Yes | Yes | Yes (requires VWF unfolding) |
| LDL-R | Yes | Yes | Unknown | Unknown |
| ASGPR | Yes | Yes (hyposialylated FVIII) | Yes | Yes (hyposialylated VWF) |
| CD206 | Yes | Probably not (antigen presentation) | No | No |
| Siglec-5 | Yes | Yes | Yes | Yes |
| CLEC4M | Unknown | Unknown | Yes | Yes |
| STAB2 | Yes | Yes | Yes | Yes |
| SCARA5 | Unknown | Unknown | Yes | Unknown |
| HSPGs | Yes | Possibly | Yes | Unlikely |
| Receptor* . | FVIII† . | Clearance?‡ . | VWF† . | Clearance?‡ . |
|---|---|---|---|---|
| LRP1 | Yes | Yes | Yes | Yes (requires VWF unfolding) |
| LDL-R | Yes | Yes | Unknown | Unknown |
| ASGPR | Yes | Yes (hyposialylated FVIII) | Yes | Yes (hyposialylated VWF) |
| CD206 | Yes | Probably not (antigen presentation) | No | No |
| Siglec-5 | Yes | Yes | Yes | Yes |
| CLEC4M | Unknown | Unknown | Yes | Yes |
| STAB2 | Yes | Yes | Yes | Yes |
| SCARA5 | Unknown | Unknown | Yes | Unknown |
| HSPGs | Yes | Possibly | Yes | Unlikely |
HSPG, heparin sulfate proteoglycan; SCARA5, scavenger receptor class A, member 5; STAB2, stabilin 2.
The 9 receptors listed have been demonstrated at some level to bind to and, in some cases, mediate clearance of FVIII and/or VWF.
Responses indicate evidence of receptor binding to the protein.
Responses indicate evidence for FVIII and VWF clearance by each receptor.