Parameters that potentially modulate clearance of VWF
| Parameters . | Affects VWF interaction with . |
|---|---|
| Patient-related parameters | |
| • Body weight | • ASGPR |
| • Age | • ASGPR |
| • Diet | • ASGPR |
| • ABO antigen status | • ? |
| • Vascular integrity | • LRP1 |
| • Inflammatory state | • ASGPR |
| Receptor-related parameters | |
| • Repertoire, expression level, activity | • ? |
| • Sequence variations | • CLEC4M, LRP1 |
| VWF-related parameters | |
| • Sequence variations (polymorphisms, mutations) | • LRP1 |
| • Glycosylation variations | • ASGPR, Siglec-5 |
| • Proteins associated with VWF (FVIII, osteoprotegerin, galectins, etc) | • ? |
| • Activation state, unfolding | • LRP1 |
| Parameters . | Affects VWF interaction with . |
|---|---|
| Patient-related parameters | |
| • Body weight | • ASGPR |
| • Age | • ASGPR |
| • Diet | • ASGPR |
| • ABO antigen status | • ? |
| • Vascular integrity | • LRP1 |
| • Inflammatory state | • ASGPR |
| Receptor-related parameters | |
| • Repertoire, expression level, activity | • ? |
| • Sequence variations | • CLEC4M, LRP1 |
| VWF-related parameters | |
| • Sequence variations (polymorphisms, mutations) | • LRP1 |
| • Glycosylation variations | • ASGPR, Siglec-5 |
| • Proteins associated with VWF (FVIII, osteoprotegerin, galectins, etc) | • ? |
| • Activation state, unfolding | • LRP1 |