Selected extracellular biomarkers with AUC higher than 0.75
| Metabolites . | HMDB ID . | SAGM (extracellular metabolites) . | |||||
|---|---|---|---|---|---|---|---|
| Phase 1 vs phase 2 . | Phase 1 vs phase 3 . | Phase 2 vs phase 3 . | |||||
| AUC . | Student t tests . | AUC . | Student t tests . | AUC . | Student t tests . | ||
| Lactic acid | HMDB00190 | 0.99 | 9.0E-25 | 1.00 | 2.4E-72 | 0.93 | 1.8E-31 |
| Nicotinamide | HMDB01406 | 0.98 | 3.2E-25 | 1.00 | 3.4E-81 | 0.97 | 6.7E-41 |
| Glucose | HMDB00122 | 0.97 | 9.5E-27 | 1.00 | 2.3E-51 | 0.93 | 9.1E-25 |
| 5-oxoproline | HMDB00267 | 0.94 | 7.7E-20 | 1.00 | 6.7E-66 | 0.89 | 1.2E-25 |
| Malic acid | HMDB00156 | 0.90 | 3.0E-16 | 0.98 | 3.4E-53 | 0.84 | 2.6E-17 |
| Adenine | HMDB00034 | 0.89 | 3.0E-14 | 0.98 | 2.2E-56 | 0.78 | 3.9E-11 |
| Hypoxanthine | HMDB00157 | 0.86 | 2.7E-14 | 1.00 | 1.6E-88 | 0.98 | 2.6E-50 |
| Xanthine | HMDB00292 | 0.86 | 2.3E-13 | 0.99 | 2.1E-57 | 0.92 | 1.3E-30 |
| Metabolites . | HMDB ID . | SAGM (extracellular metabolites) . | |||||
|---|---|---|---|---|---|---|---|
| Phase 1 vs phase 2 . | Phase 1 vs phase 3 . | Phase 2 vs phase 3 . | |||||
| AUC . | Student t tests . | AUC . | Student t tests . | AUC . | Student t tests . | ||
| Lactic acid | HMDB00190 | 0.99 | 9.0E-25 | 1.00 | 2.4E-72 | 0.93 | 1.8E-31 |
| Nicotinamide | HMDB01406 | 0.98 | 3.2E-25 | 1.00 | 3.4E-81 | 0.97 | 6.7E-41 |
| Glucose | HMDB00122 | 0.97 | 9.5E-27 | 1.00 | 2.3E-51 | 0.93 | 9.1E-25 |
| 5-oxoproline | HMDB00267 | 0.94 | 7.7E-20 | 1.00 | 6.7E-66 | 0.89 | 1.2E-25 |
| Malic acid | HMDB00156 | 0.90 | 3.0E-16 | 0.98 | 3.4E-53 | 0.84 | 2.6E-17 |
| Adenine | HMDB00034 | 0.89 | 3.0E-14 | 0.98 | 2.2E-56 | 0.78 | 3.9E-11 |
| Hypoxanthine | HMDB00157 | 0.86 | 2.7E-14 | 1.00 | 1.6E-88 | 0.98 | 2.6E-50 |
| Xanthine | HMDB00292 | 0.86 | 2.3E-13 | 0.99 | 2.1E-57 | 0.92 | 1.3E-30 |
| Metabolites . | HMDB ID . | AS3 (extracellular metabolites) . | |||||
|---|---|---|---|---|---|---|---|
| Phase 1 vs phase 2 . | Phase 1 vs phase 3 . | Phase 2 vs phase 3 . | |||||
| AUC . | Student t tests . | AUC . | Student t tests . | AUC . | Student t tests . | ||
| Lactic acid | HMDB00190 | 1.00 | 2.8E-03 | 1.00 | 1.0E-09 | 0.91 | 3.3E-03 |
| Nicotinamide | HMDB01406 | 1.00 | 2.9E-04 | 1.00 | 2.8E-11 | 0.98 | 6.9E-04 |
| Glucose | HMDB00122 | 0.78 | 1.2E-01 | 0.76 | 1.7E-02 | 1.00 | 1.4E-03 |
| 5-oxoproline | HMDB00267 | 1.00 | 2.6E-03 | 1.00 | 5.2E-10 | 0.92 | 2.7E-03 |
| Malic acid | HMDB00156 | 0.94 | 2.1E-02 | 1.00 | 3.8E-09 | 0.98 | 2.4E-04 |
| Adenine | HMDB00034 | 0.91 | 5.8E-02 | 0.99 | 3.6E-04 | 0.80 | 2.8E-01 |
| Hypoxanthine | HMDB00157 | 1.00 | 2.4E-06 | 1.00 | 1.4E-16 | 1.00 | 3.0E-06 |
| Xanthine | HMDB00292 | 1.00 | 6.3E-05 | 1.00 | 2.9E-15 | 1.00 | 7.5E-07 |
| Metabolites . | HMDB ID . | AS3 (extracellular metabolites) . | |||||
|---|---|---|---|---|---|---|---|
| Phase 1 vs phase 2 . | Phase 1 vs phase 3 . | Phase 2 vs phase 3 . | |||||
| AUC . | Student t tests . | AUC . | Student t tests . | AUC . | Student t tests . | ||
| Lactic acid | HMDB00190 | 1.00 | 2.8E-03 | 1.00 | 1.0E-09 | 0.91 | 3.3E-03 |
| Nicotinamide | HMDB01406 | 1.00 | 2.9E-04 | 1.00 | 2.8E-11 | 0.98 | 6.9E-04 |
| Glucose | HMDB00122 | 0.78 | 1.2E-01 | 0.76 | 1.7E-02 | 1.00 | 1.4E-03 |
| 5-oxoproline | HMDB00267 | 1.00 | 2.6E-03 | 1.00 | 5.2E-10 | 0.92 | 2.7E-03 |
| Malic acid | HMDB00156 | 0.94 | 2.1E-02 | 1.00 | 3.8E-09 | 0.98 | 2.4E-04 |
| Adenine | HMDB00034 | 0.91 | 5.8E-02 | 0.99 | 3.6E-04 | 0.80 | 2.8E-01 |
| Hypoxanthine | HMDB00157 | 1.00 | 2.4E-06 | 1.00 | 1.4E-16 | 1.00 | 3.0E-06 |
| Xanthine | HMDB00292 | 1.00 | 6.3E-05 | 1.00 | 2.9E-15 | 1.00 | 7.5E-07 |
HMDB, human metabolome database.