Patients with multirefractory ITP receiving a combination of IS and TPO-RA
| Patients . | Treatments received before multirefractory ITP . | Treatment status of multirefractory ITP before IS/TPO-RA association . | IS/TPO-RA association/other ITP treatments . | Response to current treatment . | Follow-up after IS/TPO-RA association . |
|---|---|---|---|---|---|
| 1 | CST, IVIG, splenectomy, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 75 mg | AZA (NR), anti-Rh D (NR), vincristine (NR) | CST 15 mg, AZA 150 mg, romiplostim 10 μg/kg bw | CR | 12 |
| 2 | CST, vinblastine, eltrombopag 75 mg, RTX 1 g ×2, splenectomy, romiplostim 10 μg/kg bw | TPO-Ra association (NR), romiplostim 10 μg/kg bw + CST 10 mg/d (NR) | CYC 1 g ×3, eltrombopag 75 mg | CR | 17 |
| 3 | CST, IVIG, AZA, splenectomy, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 75 mg | vinblastine (NR), cyclosporine (NR), dapsone (NR), tacrolimus (NR), IVIG (NR) | MMF 1 g ×2 + eltrombopag 50 mg | CR | 29 |
| 4 | CST, IVIG, vinblastine, splenectomy, RTX 375 mg/m2 ×4, eltrombopag 100 mg, romiplostim 10 μg/kg bw | IVIG (NR), danazol (NR) | MMF 1 g ×2 + eltrombopag 75 mg | CR | 13 |
| 5 | CST, IVIG, AZA, splenectomy, romiplostim 10 μg/kg bw, RTX 375 mg/m2 ×4, eltrombopag 75 mg | CYC (NR), vincristine (NR), AZA (NR), cyclosporine (NR) | Autologous HSCT + eltrombopag 75 mg | CR | 32 |
| 6 | Splenectomy, romiplostim 10 μg/kg bw, eltrombopag 75 mg, RTX 1 g ×2 | _ | MMF 1 g ×2 + CST 10 mg + romiplostim 10 μg/kg bw | R | 17 |
| 7 | CST, IVIG, RTX 1 g ×2,dapsone,eltrombopag 75 mg, romiplostim 10 μg/kg bw, splenectomy, | AZA (NR) | Romiplostim 10 μg/kg bw + cyclosporine | R | 12 |
| 8 | CST, IVIG, HCQ, vinblastine, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 150 mg, splenectomy | Dexamethasone (NR) | MMF 1 g ×2 + romiplostim 10 μg/kg bw (NR), tacrolimus (NR), CYC (transient response), HCQ (NR), cyclosporine + IVIG (NR) | NR | 26 |
| 9 | CST, IVIG, vinblastine, splenectomy, RTX 1 g ×2, eltrombopag 75 mg, CYC, romiplostim 10 μg/kg bw | MMF (NR) | Eltrombopag 100 mg; MMF 1 g ×2 | NR | 6 |
| 10 | CST, IVIG, HCQ, RTX 1 g ×2, romiplostim 10 μg/kg bw, splenectomy, eltrombopag 75 mg | Vinblastine (NR) | CYC 1 g ×4 + CST + romiplostim 10 μg/kg bw (NR) | NR | 6 |
| Patients . | Treatments received before multirefractory ITP . | Treatment status of multirefractory ITP before IS/TPO-RA association . | IS/TPO-RA association/other ITP treatments . | Response to current treatment . | Follow-up after IS/TPO-RA association . |
|---|---|---|---|---|---|
| 1 | CST, IVIG, splenectomy, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 75 mg | AZA (NR), anti-Rh D (NR), vincristine (NR) | CST 15 mg, AZA 150 mg, romiplostim 10 μg/kg bw | CR | 12 |
| 2 | CST, vinblastine, eltrombopag 75 mg, RTX 1 g ×2, splenectomy, romiplostim 10 μg/kg bw | TPO-Ra association (NR), romiplostim 10 μg/kg bw + CST 10 mg/d (NR) | CYC 1 g ×3, eltrombopag 75 mg | CR | 17 |
| 3 | CST, IVIG, AZA, splenectomy, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 75 mg | vinblastine (NR), cyclosporine (NR), dapsone (NR), tacrolimus (NR), IVIG (NR) | MMF 1 g ×2 + eltrombopag 50 mg | CR | 29 |
| 4 | CST, IVIG, vinblastine, splenectomy, RTX 375 mg/m2 ×4, eltrombopag 100 mg, romiplostim 10 μg/kg bw | IVIG (NR), danazol (NR) | MMF 1 g ×2 + eltrombopag 75 mg | CR | 13 |
| 5 | CST, IVIG, AZA, splenectomy, romiplostim 10 μg/kg bw, RTX 375 mg/m2 ×4, eltrombopag 75 mg | CYC (NR), vincristine (NR), AZA (NR), cyclosporine (NR) | Autologous HSCT + eltrombopag 75 mg | CR | 32 |
| 6 | Splenectomy, romiplostim 10 μg/kg bw, eltrombopag 75 mg, RTX 1 g ×2 | _ | MMF 1 g ×2 + CST 10 mg + romiplostim 10 μg/kg bw | R | 17 |
| 7 | CST, IVIG, RTX 1 g ×2,dapsone,eltrombopag 75 mg, romiplostim 10 μg/kg bw, splenectomy, | AZA (NR) | Romiplostim 10 μg/kg bw + cyclosporine | R | 12 |
| 8 | CST, IVIG, HCQ, vinblastine, RTX 375 mg/m2 ×4, romiplostim 10 μg/kg bw, eltrombopag 150 mg, splenectomy | Dexamethasone (NR) | MMF 1 g ×2 + romiplostim 10 μg/kg bw (NR), tacrolimus (NR), CYC (transient response), HCQ (NR), cyclosporine + IVIG (NR) | NR | 26 |
| 9 | CST, IVIG, vinblastine, splenectomy, RTX 1 g ×2, eltrombopag 75 mg, CYC, romiplostim 10 μg/kg bw | MMF (NR) | Eltrombopag 100 mg; MMF 1 g ×2 | NR | 6 |
| 10 | CST, IVIG, HCQ, RTX 1 g ×2, romiplostim 10 μg/kg bw, splenectomy, eltrombopag 75 mg | Vinblastine (NR) | CYC 1 g ×4 + CST + romiplostim 10 μg/kg bw (NR) | NR | 6 |
AZA, azathioprine; bw, body weight; CST, corticosteroids; CYC, cyclophosphamide; HCQ, hydroxychloroquine; IS, immunosuppressant therapy; IVIG, IV immunoglobulin; MMF, mycophenolate mofetil; NR, nonresponse.