Characteristics of patients at baseline
| . | Arm A: MPT-T . | Arm B: MPR-R . |
|---|---|---|
| Number | 318 | 319 |
| Median age, years (range) | 72 (60-91) | 73 (60-87) |
| Age ≥76 years, N (%) | 105 (33) | 110 (34) |
| Sex, N (%) | ||
| Male | 161 (51) | 185 (58) |
| Female | 157 (49) | 134 (42) |
| WHO performance status, N (%) | ||
| 0 | 104 (33) | 117 (37) |
| 1 | 152 (48) | 145 (45) |
| 2 | 43 (14) | 46 (14) |
| 3 | 6 (2) | 5 (2) |
| Unknown | 13 (4) | 6 (2) |
| M-protein subtype, N (%) | ||
| IgG | 202 (64) | 202 (63) |
| IgA | 87 (27) | 75 (24) |
| IgD | 5 (2) | 3 (1) |
| Light chain only | 22 (7) | 38 (12) |
| Unknown | 2 (1) | 1 (0) |
| ISS, N (%) | ||
| I | 75 (24) | 82 (26) |
| II | 153 (48) | 151 (47) |
| III | 83 (26) | 82 (26) |
| Unknown | 7 (2) | 4 (1) |
| Lactate dehydrogenase elevated, N (%) | 24 (8) | 33 (10) |
| Lytic bone disease (%) | 209 (66) | 219 (69) |
| FISH performed % | 231 (73) | 248 (78) |
| FISH abnormality present if performed, N (%) | ||
| 17p13 loss | 25/214 (12) | 19/221 (9) |
| t(4;14) | 21/224 (9) | 19/221 (8) |
| t(14;16) | 3/194 (2) | 10/214 (5) |
| 1q21 gain | 64/167 (38) | 67/188 (36) |
| . | Arm A: MPT-T . | Arm B: MPR-R . |
|---|---|---|
| Number | 318 | 319 |
| Median age, years (range) | 72 (60-91) | 73 (60-87) |
| Age ≥76 years, N (%) | 105 (33) | 110 (34) |
| Sex, N (%) | ||
| Male | 161 (51) | 185 (58) |
| Female | 157 (49) | 134 (42) |
| WHO performance status, N (%) | ||
| 0 | 104 (33) | 117 (37) |
| 1 | 152 (48) | 145 (45) |
| 2 | 43 (14) | 46 (14) |
| 3 | 6 (2) | 5 (2) |
| Unknown | 13 (4) | 6 (2) |
| M-protein subtype, N (%) | ||
| IgG | 202 (64) | 202 (63) |
| IgA | 87 (27) | 75 (24) |
| IgD | 5 (2) | 3 (1) |
| Light chain only | 22 (7) | 38 (12) |
| Unknown | 2 (1) | 1 (0) |
| ISS, N (%) | ||
| I | 75 (24) | 82 (26) |
| II | 153 (48) | 151 (47) |
| III | 83 (26) | 82 (26) |
| Unknown | 7 (2) | 4 (1) |
| Lactate dehydrogenase elevated, N (%) | 24 (8) | 33 (10) |
| Lytic bone disease (%) | 209 (66) | 219 (69) |
| FISH performed % | 231 (73) | 248 (78) |
| FISH abnormality present if performed, N (%) | ||
| 17p13 loss | 25/214 (12) | 19/221 (9) |
| t(4;14) | 21/224 (9) | 19/221 (8) |
| t(14;16) | 3/194 (2) | 10/214 (5) |
| 1q21 gain | 64/167 (38) | 67/188 (36) |