Clinical predictors of IL-2 response
| . | No response (MR/SD/PD) . | Response (PR) . | P . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N . | Median . | Minimum . | Maximum . | N . | Median . | Minimum . | Maximum . | ||
| Age, y | 13 | 61 | 29 | 70 | 20 | 50 | 22 | 72 | .044 |
| No. of prior therapies | 13 | 3 | 1 | 4 | 20 | 2 | 1 | 4 | .6 |
| Prednisone start dose, mg | 13 | 25 | 3 | 40 | 20 | 20 | 5 | 50 | .9 |
| No. of cGVHD sites | 13 | 4 | 1 | 6 | 20 | 5 | 2 | 7 | .27 |
| Time from HSCT to start of IL-2, d | 13 | 917 | 348 | 2145 | 20 | 508 | 270 | 1065 | .005 |
| Time from cGVHD to start of IL-2, d | 13 | 461 | 119 | 1880 | 20 | 249 | 28 | 847 | .03 |
| Time from HSCT to cGVHD, d | 13 | 265 | 153 | 996 | 20 | 266 | 46 | 433 | .35 |
| Prednisone dose reduction, week 12, % | 13 | 0 | 0 | 50 | 20 | 25 | 0 | 75 | .15 |
| . | No response (MR/SD/PD) . | Response (PR) . | P . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N . | Median . | Minimum . | Maximum . | N . | Median . | Minimum . | Maximum . | ||
| Age, y | 13 | 61 | 29 | 70 | 20 | 50 | 22 | 72 | .044 |
| No. of prior therapies | 13 | 3 | 1 | 4 | 20 | 2 | 1 | 4 | .6 |
| Prednisone start dose, mg | 13 | 25 | 3 | 40 | 20 | 20 | 5 | 50 | .9 |
| No. of cGVHD sites | 13 | 4 | 1 | 6 | 20 | 5 | 2 | 7 | .27 |
| Time from HSCT to start of IL-2, d | 13 | 917 | 348 | 2145 | 20 | 508 | 270 | 1065 | .005 |
| Time from cGVHD to start of IL-2, d | 13 | 461 | 119 | 1880 | 20 | 249 | 28 | 847 | .03 |
| Time from HSCT to cGVHD, d | 13 | 265 | 153 | 996 | 20 | 266 | 46 | 433 | .35 |
| Prednisone dose reduction, week 12, % | 13 | 0 | 0 | 50 | 20 | 25 | 0 | 75 | .15 |
Additional nonsignificant variables: patient sex, conditioning regimen intensity (MAC, RIC), HLA match (HLA-matched related donor, HLA-matched unrelated donor, mismatched), prior hematologic malignancy (lymphoid, myeloid), specific cGVHD agents (eg, sirolimus, mycophenolate mofetil). Note: Other baseline patient and transplant characteristics listed in Table 1 are not included in this table and none of them was different between PR and no PR at the 0.05 level.