Components of platelet α-granules active on angiogenesis and inflammation
| Action . | Components . |
|---|---|
| Proangiogenic | VEGF-A; VEGF-C; PDF; fibroblast growth factor-2; EGF; HGF; IGF-1; TGFβ; ANGPT1 |
| Antiangiogenic | TSP-1; PF-4; PA-I; S1P; endostatin |
| Metalloproteinases | MMP-1; MMP-2; MMP-3; MMP-9; MMP-14; TIMP-1; TIMP-2; TIMP-4; ADAM-10; ADAM-17; ADAMTS-13 |
| Proinflammatory | CXCL1(GROα); CXCL-4(PF4); CXCL-5(ENA-78); CXCL-7(PBP); CXCL-8(IL-8); CXCL-12(SDF-1); CCL-2(MCP-1); CCL-3(MIP-1α); CCL-5(RANTES); CCL-7(MCP-3); CCL-17(TARC); IL1-β3 ; PAF acetylhydrolase |
| Action . | Components . |
|---|---|
| Proangiogenic | VEGF-A; VEGF-C; PDF; fibroblast growth factor-2; EGF; HGF; IGF-1; TGFβ; ANGPT1 |
| Antiangiogenic | TSP-1; PF-4; PA-I; S1P; endostatin |
| Metalloproteinases | MMP-1; MMP-2; MMP-3; MMP-9; MMP-14; TIMP-1; TIMP-2; TIMP-4; ADAM-10; ADAM-17; ADAMTS-13 |
| Proinflammatory | CXCL1(GROα); CXCL-4(PF4); CXCL-5(ENA-78); CXCL-7(PBP); CXCL-8(IL-8); CXCL-12(SDF-1); CCL-2(MCP-1); CCL-3(MIP-1α); CCL-5(RANTES); CCL-7(MCP-3); CCL-17(TARC); IL1-β3 ; PAF acetylhydrolase |
Table adapted from Menter et al.