ACT approaches
| ACTs . | Advantages . | Challenges . | Disadvantages . |
|---|---|---|---|
| TCR | Broader array of possible targets | Find target antigens that are tumor specific | Tumor escape |
| MHC restricted | |||
| Risk of cross-reactivity | |||
| Require vectors | |||
| Possible mispairing with endogenous TCR | |||
| CAR | Highly tumor specific | Find target antigens that are tumor specific | Tumor escape |
| HLA independent | Cytokine storm | ||
| Antigens recognized not limited to proteins | Limited to extracellular antigens | ||
| Recognizes soluble antigen | Require vectors | ||
| MILs | No vectors involved in production | Identify antigens being recognized | Heterogeneous product |
| Polyclonal (multiple targets) | Increase tumor specificity | Lower efficiency |
| ACTs . | Advantages . | Challenges . | Disadvantages . |
|---|---|---|---|
| TCR | Broader array of possible targets | Find target antigens that are tumor specific | Tumor escape |
| MHC restricted | |||
| Risk of cross-reactivity | |||
| Require vectors | |||
| Possible mispairing with endogenous TCR | |||
| CAR | Highly tumor specific | Find target antigens that are tumor specific | Tumor escape |
| HLA independent | Cytokine storm | ||
| Antigens recognized not limited to proteins | Limited to extracellular antigens | ||
| Recognizes soluble antigen | Require vectors | ||
| MILs | No vectors involved in production | Identify antigens being recognized | Heterogeneous product |
| Polyclonal (multiple targets) | Increase tumor specificity | Lower efficiency |