Multivariate analysis of factors that influence the development of acute GVHD grades I-IV, II-IV, and III-IV following the initial graft infusion before or without the onset of mixed chimerism
| . | HR (95% CI) . | P . |
|---|---|---|
| Acute GVHD grades I-IV | ||
| Alemtuzumab level (continuous variable) | 0.422 (0.255-0.698) | <.001 |
| HLA matched sibling | 1.0 | |
| Matched unrelated donor | 4.300 (1.004-18.419) | .049 |
| Mismatched donor, 1 or 2 alleles | 2.082 (0.404-10.734) | .381 |
| Acute GVHD grades II-IV | ||
| Alemtuzumab level (continuous variable) | 0.477 (0.266-0.855) | .013 |
| HLA matched sibling | 1.0 | |
| Matched unrelated donor | 5.461 (0.720-41.426) | .101 |
| Mismatched donor, 1 or 2 alleles | 2.387 (0.248-22.948) | .451 |
| Acute GVHD grades III-IV | ||
| Alemtuzumab level (continuous variable) | 0.516 (0.260-1.025) | .059 |
| HLA matched sibling | NR* | |
| Matched unrelated donor | NR* | |
| Mismatched donor, 1 or 2 alleles | NR* |
| . | HR (95% CI) . | P . |
|---|---|---|
| Acute GVHD grades I-IV | ||
| Alemtuzumab level (continuous variable) | 0.422 (0.255-0.698) | <.001 |
| HLA matched sibling | 1.0 | |
| Matched unrelated donor | 4.300 (1.004-18.419) | .049 |
| Mismatched donor, 1 or 2 alleles | 2.082 (0.404-10.734) | .381 |
| Acute GVHD grades II-IV | ||
| Alemtuzumab level (continuous variable) | 0.477 (0.266-0.855) | .013 |
| HLA matched sibling | 1.0 | |
| Matched unrelated donor | 5.461 (0.720-41.426) | .101 |
| Mismatched donor, 1 or 2 alleles | 2.387 (0.248-22.948) | .451 |
| Acute GVHD grades III-IV | ||
| Alemtuzumab level (continuous variable) | 0.516 (0.260-1.025) | .059 |
| HLA matched sibling | NR* | |
| Matched unrelated donor | NR* | |
| Mismatched donor, 1 or 2 alleles | NR* |
The final model for each grade analysis is shown. The initial models included the covariates of alemtuzumab level on the day of graft infusion, HLA match, patient age at the time of HCT, and GVHD prophylaxis.
Not reportable. No patients in the matched sibling donor group developed grades III-IV acute GVHD. This results in the observed hazard being exactly zero for the group, and therefore the HR estimates are not computable.