Table 6

Risk of sclerosis in patients with chronic GVHD, according to recipient HLA-DP variations

Recipient variationHR* (95% CI)P
HLA-DPA1 rs987870 CC vs CT or TT genotypes 2.66 (1.18-5.97) .02 
DPA1*01:03∼DPB1*04:01 haplotype 1.59 (1.11-2.27) .01 
Q∼GPM P1 pocket 0.64 (0.43-0.96) .03 
Recipient variationHR* (95% CI)P
HLA-DPA1 rs987870 CC vs CT or TT genotypes 2.66 (1.18-5.97) .02 
DPA1*01:03∼DPB1*04:01 haplotype 1.59 (1.11-2.27) .01 
Q∼GPM P1 pocket 0.64 (0.43-0.96) .03 
*

Adjusted for stem cell graft source, HLA matching, ABO compatibility, TBI dose, and principal components.

Heterodimers with Q (glutamine) at position 31 of the HLA-DPα chain and GPM at positions 85 to 87 of the HLA-DPβ chain.

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