Table 3

Risk of sclerosis in patients with chronic GVHD, according to SNPs in donors and recipients

GenomeGeneSNPAlleles*NModelGroups comparedUnadjustedAdjusted†
HR (95% CI)PHR (95% CI)P
Donor BANK1 rs10516487 T/C 807 Allelic TT vs TC vs CC 0.83 (0.66-1.04) .11 0.84 (0.67-1.05) .12 
     Dominant TT or TC vs CC 0.91 (0.68-1.20) .50 0.92 (0.69-1.22) .55 
     Recessive TT vs TC or CC 0.43 (0.21-0.88) .02 0.43 (0.21-0.87) .02 
Donor CD247 rs2056626 G/T 808 Allelic GG vs GT vs TT 1.23 (1.01-1.51) .04 1.23 (1.00-1.51) .04 
     Dominant GG or GT vs TT 1.58 (1.14-2.18) .006 1.57 (1.13-2.18) .007 
     Recessive GG vs GT or TT 1.05 (0.72-1.53) .82 1.04 (0.71-1.53) .84 
Recipient CD247 rs2056626 G/T 776 Allelic GG vs GT vs TT 1.27 (1.04-1.55) .02 1.24 (1.01-1.52) .04 
     Dominant GG or GT vs TT 1.62 (1.17-2.24) .004 1.66 (1.19-2.32) .003 
     Recessive GG vs GT or TT 1.13 (0.78-1.64) .53 1.04 (0.71-1.52) .85 
Donor HLA-DPA1 rs987870 C/T 793 Allelic CC vs CT vs TT 0.89 (0.66-1.20) .45 0.89 (0.66-1.20) .44 
     Dominant CC or CT vs TT 0.77 (0.55-1.07) .12 0.76 (0.54-1.06) .11 
     Recessive CC vs CT or TT 2.44 (1.20-4.96) .01 2.50 (1.22-5.11) .01 
Recipient HLA-DPA1 rs987870 C/T 767 Allelic CC vs CT vs TT 0.81 (0.59-1.12) .20 0.84 (0.61-1.15) .28 
     Dominant CC or CT vs TT 0.69 (0.49-0.99) .04 0.72 (0.50-1.03) .07 
     Recessive CC vs CT or TT 2.17 (1.02-4.63) .04 2.13 (1.00-4.54) .05 
GenomeGeneSNPAlleles*NModelGroups comparedUnadjustedAdjusted†
HR (95% CI)PHR (95% CI)P
Donor BANK1 rs10516487 T/C 807 Allelic TT vs TC vs CC 0.83 (0.66-1.04) .11 0.84 (0.67-1.05) .12 
     Dominant TT or TC vs CC 0.91 (0.68-1.20) .50 0.92 (0.69-1.22) .55 
     Recessive TT vs TC or CC 0.43 (0.21-0.88) .02 0.43 (0.21-0.87) .02 
Donor CD247 rs2056626 G/T 808 Allelic GG vs GT vs TT 1.23 (1.01-1.51) .04 1.23 (1.00-1.51) .04 
     Dominant GG or GT vs TT 1.58 (1.14-2.18) .006 1.57 (1.13-2.18) .007 
     Recessive GG vs GT or TT 1.05 (0.72-1.53) .82 1.04 (0.71-1.53) .84 
Recipient CD247 rs2056626 G/T 776 Allelic GG vs GT vs TT 1.27 (1.04-1.55) .02 1.24 (1.01-1.52) .04 
     Dominant GG or GT vs TT 1.62 (1.17-2.24) .004 1.66 (1.19-2.32) .003 
     Recessive GG vs GT or TT 1.13 (0.78-1.64) .53 1.04 (0.71-1.52) .85 
Donor HLA-DPA1 rs987870 C/T 793 Allelic CC vs CT vs TT 0.89 (0.66-1.20) .45 0.89 (0.66-1.20) .44 
     Dominant CC or CT vs TT 0.77 (0.55-1.07) .12 0.76 (0.54-1.06) .11 
     Recessive CC vs CT or TT 2.44 (1.20-4.96) .01 2.50 (1.22-5.11) .01 
Recipient HLA-DPA1 rs987870 C/T 767 Allelic CC vs CT vs TT 0.81 (0.59-1.12) .20 0.84 (0.61-1.15) .28 
     Dominant CC or CT vs TT 0.69 (0.49-0.99) .04 0.72 (0.50-1.03) .07 
     Recessive CC vs CT or TT 2.17 (1.02-4.63) .04 2.13 (1.00-4.54) .05 
*

The first allele is designated as the minor allele and the second allele is designated as the major allele.

†

Adjusted for stem cell graft source, HLA matching, ABO compatibility, TBI dose, and principal components.

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