Results of HSCT in children (≤18 y of age) with CML in first chronic phase
| Author . | Year . | Patients (No.) . | Disease phase at HSCT . | Donor source . | Overall survival . | Notes . |
|---|---|---|---|---|---|---|
| Cwynarski93 | 2003 | 314 | CP1, n = 253 | MSD | 75% (CP1, MSD, n = 156) | EBMT registry data |
| Other, n = 61 | VUD | 65% (CP1, VUD, n = 97) | ||||
| Suttorp91 | 2009 | 176 | CP1, n = 158 | MRD | At 5 y: | |
| Other, n = 18 | MUD | 87 ± 11% (MSD, n = 41) | ||||
| 52 ± 9% (MUD, n = 71) | ||||||
| 45 ± 16% (MMD, n = 55) | ||||||
| Muramatsu94 | 2010 | 125 | CP1, n = 88 | Unrelated | 59.3% at 5 y | |
| Other, n = 37 | ||||||
| Chaudhury88 | 2014 | 177 | CP1 and hematologic remission | 71% (95% CI, 65-77) at 5 y | CIBMTR data |
| Author . | Year . | Patients (No.) . | Disease phase at HSCT . | Donor source . | Overall survival . | Notes . |
|---|---|---|---|---|---|---|
| Cwynarski93 | 2003 | 314 | CP1, n = 253 | MSD | 75% (CP1, MSD, n = 156) | EBMT registry data |
| Other, n = 61 | VUD | 65% (CP1, VUD, n = 97) | ||||
| Suttorp91 | 2009 | 176 | CP1, n = 158 | MRD | At 5 y: | |
| Other, n = 18 | MUD | 87 ± 11% (MSD, n = 41) | ||||
| 52 ± 9% (MUD, n = 71) | ||||||
| 45 ± 16% (MMD, n = 55) | ||||||
| Muramatsu94 | 2010 | 125 | CP1, n = 88 | Unrelated | 59.3% at 5 y | |
| Other, n = 37 | ||||||
| Chaudhury88 | 2014 | 177 | CP1 and hematologic remission | 71% (95% CI, 65-77) at 5 y | CIBMTR data |
Only studies with >100 cases are listed.
CI, confidence interval; CIBMTR, Center for International Blood and Marrow Transplant Research; CP1, first chronic phase; EBMT, European Group for Blood and Marrow Transplantation; HSCT, hematopoietic stem cell therapy; MMD, mismatched donor; MRD, matched-related donor; MSD, matched-sibling donor; MUD, matched-unrelated donor; VUD, volunteer-unrelated donor.