RNA-Seq in HSCT recipients with TMA and gene variants compared with HSCT controls without TMA and without gene variants
| Pathway . | Relative expression of pathway genes in patients with variants compared with those without variants . | |||||
|---|---|---|---|---|---|---|
| C5 variants . | CD46 variants . | C3 variants . | ADAMTS13 variants . | CD55 variants . | CFD variants . | |
| Genes involved in initial triggering of complement | — | ↑ (P = 1.8E-08) | ↑ (P = 9.8E-03) | ↑ (P = 2.6E-05) | ↑ (P = 3.9E-04) | − |
| Genes involved in regulation of complement cascade | — | ↑ (P = 2.1E-09) | ↑ (P = 2.8E-02) | ↑ (P = 2.1E-03) | ↑ (P = 1.7E-06) | ↑ (P = 3.0E-06) |
| Complement and coagulation cascades | — | ↑ (P = 2.0E-05) | ↑ (P = 7.7E-05) | ↑ (P = 2.1E-03) | ↑ (P = 4.6E-04) | ↑ (P = 4.8E-04) |
| Genes involved in complement cascade | ↑ (P = 1.5E-03) | ↑ (P = 7.6E-08) | ↑ (P = 3.3E-03) | ↑ (P = 2.1E-04) | ↑ (P = 1.7E-06) | ↑ (P = 2.1E-06) |
| Complement pathway | ↑ (P = 5.4E-06) | ↑ (P = 1.9E-06) | ↑ (P = 1.4E-02) | ↑ (P = 1.1E-04) | ↑ (P = 1.1E-03) | — |
| Lectin-induced complement pathway | ↑ (P = 3.3E-03) | ↑ (P = 9.3E-04) | — | — | — | — |
| Classical complement pathway | ↑ (P = 1.9E-07) | ↑ (P = 1.2E-02) | — | — | — | — |
| Pathway . | Relative expression of pathway genes in patients with variants compared with those without variants . | |||||
|---|---|---|---|---|---|---|
| C5 variants . | CD46 variants . | C3 variants . | ADAMTS13 variants . | CD55 variants . | CFD variants . | |
| Genes involved in initial triggering of complement | — | ↑ (P = 1.8E-08) | ↑ (P = 9.8E-03) | ↑ (P = 2.6E-05) | ↑ (P = 3.9E-04) | − |
| Genes involved in regulation of complement cascade | — | ↑ (P = 2.1E-09) | ↑ (P = 2.8E-02) | ↑ (P = 2.1E-03) | ↑ (P = 1.7E-06) | ↑ (P = 3.0E-06) |
| Complement and coagulation cascades | — | ↑ (P = 2.0E-05) | ↑ (P = 7.7E-05) | ↑ (P = 2.1E-03) | ↑ (P = 4.6E-04) | ↑ (P = 4.8E-04) |
| Genes involved in complement cascade | ↑ (P = 1.5E-03) | ↑ (P = 7.6E-08) | ↑ (P = 3.3E-03) | ↑ (P = 2.1E-04) | ↑ (P = 1.7E-06) | ↑ (P = 2.1E-06) |
| Complement pathway | ↑ (P = 5.4E-06) | ↑ (P = 1.9E-06) | ↑ (P = 1.4E-02) | ↑ (P = 1.1E-04) | ↑ (P = 1.1E-03) | — |
| Lectin-induced complement pathway | ↑ (P = 3.3E-03) | ↑ (P = 9.3E-04) | — | — | — | — |
| Classical complement pathway | ↑ (P = 1.9E-07) | ↑ (P = 1.2E-02) | — | — | — | — |
The P values were false discovery rate adjusted for testing all pathways and gene lists in the MSigDB database. ↑, upregulated.