Comparison of identified glycoproteins between patients V125 (ZAP-70 negative) and V250 (ZAP-70 positive) which were significantly increased by TLR9 stimulation relative to nontreated (Con) CLL cells
| Protein name . | Gene name . | Unique peptides . | LFQ ratio of V125 +DSP30 vs V125 control . | LFQ ratio of V250 control vs V125 control . | LFQ ratio of V250 +DSP30 vs V125 +DSP30 . |
|---|---|---|---|---|---|
| Ig μ chain C region;Ig μ heavy chain disease protein | IGHM | 10 | 0.00 | 4.10 | 30.20 |
| CD44 antigen | CD44 | 4 | 0.67 | 0.68 | 11.41 |
| Testican-2 | SPOCK2 | 4 | 0.00 | 63.17 | 2.55 |
| Dermcidin | DCD | 2 | 2.00 | 1.39 | 2.41 |
| Coagulation factor X | F10 | 2 | 0.72 | 1.88 | 1.98 |
| Endoplasmin | HSP90B1 | 5 | 1.17 | 1.17 | 1.74 |
| Protocadherin γ-C3 | PCDHGC3 | 3 | 0.66 | 1.06 | 1.65 |
| Semaphorin-4B | SEMA4B | 3 | 0.69 | 1.81 | 1.52 |
| Plexin domain-containing protein 2 | PLXDC2 | 3 | 1.69 | 1.20 | 1.45 |
| Fibronectin | FN1 | 12 | 1.57 | 1.72 | 1.37 |
| HLA class I histocompatibility antigen | HLA-A | 1 | 0.95 | 0.88 | 1.37 |
| Collagen α-1(VI) chain | COL6A1 | 3 | 0.66 | 0.82 | 1.36 |
| Coagulation factor XIII A chain | F13A1 | 2 | 0.00 | 0.89 | 1.33 |
| Apolipoprotein B-100;apolipoprotein B-48 | APOB | 6 | 1.01 | 0.68 | 1.30 |
| CD109 antigen | CD109 | 2 | 1.05 | 1.30 | 1.17 |
| Regucalcin | RGN | 2 | 1.29 | 1.02 | 1.14 |
| Contactin-1 | CNTN1 | 2 | 0.74 | 1.01 | 1.12 |
| Chloride intracellular channel protein 1 | CLIC1 | 9 | 0.99 | 0.86 | 1.07 |
| Insulin-like growth factor-binding protein 2 | IGFBP2 | 5 | 2.25 | 0.72 | 1.04 |
| Tyrosine-protein kinase receptor Tie-1 | TIE1 | 3 | 0.77 | 1.03 | 1.03 |
| Protein name . | Gene name . | Unique peptides . | LFQ ratio of V125 +DSP30 vs V125 control . | LFQ ratio of V250 control vs V125 control . | LFQ ratio of V250 +DSP30 vs V125 +DSP30 . |
|---|---|---|---|---|---|
| Ig μ chain C region;Ig μ heavy chain disease protein | IGHM | 10 | 0.00 | 4.10 | 30.20 |
| CD44 antigen | CD44 | 4 | 0.67 | 0.68 | 11.41 |
| Testican-2 | SPOCK2 | 4 | 0.00 | 63.17 | 2.55 |
| Dermcidin | DCD | 2 | 2.00 | 1.39 | 2.41 |
| Coagulation factor X | F10 | 2 | 0.72 | 1.88 | 1.98 |
| Endoplasmin | HSP90B1 | 5 | 1.17 | 1.17 | 1.74 |
| Protocadherin γ-C3 | PCDHGC3 | 3 | 0.66 | 1.06 | 1.65 |
| Semaphorin-4B | SEMA4B | 3 | 0.69 | 1.81 | 1.52 |
| Plexin domain-containing protein 2 | PLXDC2 | 3 | 1.69 | 1.20 | 1.45 |
| Fibronectin | FN1 | 12 | 1.57 | 1.72 | 1.37 |
| HLA class I histocompatibility antigen | HLA-A | 1 | 0.95 | 0.88 | 1.37 |
| Collagen α-1(VI) chain | COL6A1 | 3 | 0.66 | 0.82 | 1.36 |
| Coagulation factor XIII A chain | F13A1 | 2 | 0.00 | 0.89 | 1.33 |
| Apolipoprotein B-100;apolipoprotein B-48 | APOB | 6 | 1.01 | 0.68 | 1.30 |
| CD109 antigen | CD109 | 2 | 1.05 | 1.30 | 1.17 |
| Regucalcin | RGN | 2 | 1.29 | 1.02 | 1.14 |
| Contactin-1 | CNTN1 | 2 | 0.74 | 1.01 | 1.12 |
| Chloride intracellular channel protein 1 | CLIC1 | 9 | 0.99 | 0.86 | 1.07 |
| Insulin-like growth factor-binding protein 2 | IGFBP2 | 5 | 2.25 | 0.72 | 1.04 |
| Tyrosine-protein kinase receptor Tie-1 | TIE1 | 3 | 0.77 | 1.03 | 1.03 |