UCB characteristics in transplanted patients only
| . | Double-unit UCB (n = 69) . | Single-unit UCB (n = 68) . | ||
|---|---|---|---|---|
| UCB-1 . | UCB-2 . | Combined . | ||
| HLA compatibility, n (%) | ||||
| 4/6 | 16 (23.2) | 18 (26.1) | 23 (33.3)* | 19 (27.9) |
| 5/6 | 48 (69.6) | 48 (69.6) | 45 (65.2)* | 36 (53.0) |
| 6/6 | 5 (7.2) | 3 (4.3) | 1 (1.5)* | 13 (19.1) |
| Cell doses, mean ± SEM | ||||
| Cryopreserved | ||||
| TNCs (× 107/kg) | 6.2 ± 0.5 | 5.9 ± 0.5 | 12.2 ± 0.9 | 6.3 ± 0.5 |
| CD34+ cells (× 105/kg) | 2.7 ± 0.2 | 2.2 ± 0.2 | 4.9 ± 0.4 | 2.6 ± 0.3 |
| Infused | ||||
| TNCs (× 107/kg) | 4.6 ± 0.4 | 4.6 ± 0.5 | 9.1 ± 0.8 | 4.7 ± 0.4 |
| CD34+ cell (× 105/kg) | 1.9 ± 0.2 | 1.5 ± 0.2 | 3.3 ± 0.3 | 1.9 ± 0.2 |
| CD45+ cell (× 107/kg) | 4.5 ± 1.1 | 3.9 ± 0.6 | 8.1 ± 1.4 | 4.1 ± 0.6 |
| CD3+ cell (× 106/kg) | 8.7 ± 0.9 | 8.5 ± 1.1 | 17.1 ± 1.6 | 7.8 ± 0.9 |
| . | Double-unit UCB (n = 69) . | Single-unit UCB (n = 68) . | ||
|---|---|---|---|---|
| UCB-1 . | UCB-2 . | Combined . | ||
| HLA compatibility, n (%) | ||||
| 4/6 | 16 (23.2) | 18 (26.1) | 23 (33.3)* | 19 (27.9) |
| 5/6 | 48 (69.6) | 48 (69.6) | 45 (65.2)* | 36 (53.0) |
| 6/6 | 5 (7.2) | 3 (4.3) | 1 (1.5)* | 13 (19.1) |
| Cell doses, mean ± SEM | ||||
| Cryopreserved | ||||
| TNCs (× 107/kg) | 6.2 ± 0.5 | 5.9 ± 0.5 | 12.2 ± 0.9 | 6.3 ± 0.5 |
| CD34+ cells (× 105/kg) | 2.7 ± 0.2 | 2.2 ± 0.2 | 4.9 ± 0.4 | 2.6 ± 0.3 |
| Infused | ||||
| TNCs (× 107/kg) | 4.6 ± 0.4 | 4.6 ± 0.5 | 9.1 ± 0.8 | 4.7 ± 0.4 |
| CD34+ cell (× 105/kg) | 1.9 ± 0.2 | 1.5 ± 0.2 | 3.3 ± 0.3 | 1.9 ± 0.2 |
| CD45+ cell (× 107/kg) | 4.5 ± 1.1 | 3.9 ± 0.6 | 8.1 ± 1.4 | 4.1 ± 0.6 |
| CD3+ cell (× 106/kg) | 8.7 ± 0.9 | 8.5 ± 1.1 | 17.1 ± 1.6 | 7.8 ± 0.9 |
The combined match score for patients in the double-unit UCB group is the minimum HLA match between the first unit and the recipient or the second unit and the recipient. For example, if UCB-1 was a 6/6 match with the recipient and UCB-2 was a 4/6 match, the match score assigned for that recipient was 4/6.