Short- and long-term mortality in the plasma and red cell cohorts, in relation to age of contributing blood donors
| . | Recipients of blood from donors aged <25 y . | Recipients of blood from donors aged 25-50 y . | Recipients of blood from donors aged >50 y . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of patients . | No. of deaths (%) . | HR (95% CI) . | No. of patients . | No. of deaths (%) . | HR (95% CI) . | No. of patients . | No. of deaths (%) . | HR (95% CI) . | |
| Plasma recipients | |||||||||
| 30-d mortality | |||||||||
| All transfused patients | 5 334 | 707 (13.3) | 0.99 (0.91-1.07) | 20 273 | 2 722 (13.4) | 1.00 (ref) | 19 607 | 2 575 (13.1) | 1.01 (0.96-1.07) |
| Patients with known dementia | 109 | 27 (24.8) | 1.22 (0.71-2.09) | 178 | 41 (23.0) | 1.00 (ref) | 87 | 24 (27.6) | 1.05 (0.61-1.80) |
| Patients with known cardiovascular disease | 540 | 118 (21.9) | 1.14 (0.93-1.41) | 1 378 | 240 (17.4) | 1.00 (ref) | 1 075 | 172 (16.0) | 0.93 (0.77-1.12) |
| Patients with known cerebrovascular disease | 393 | 80 (20.4) | 0.99 (0.78-1.27) | 947 | 184 (19.4) | 1.00 (ref) | 590 | 95 (16.1) | 0.76 (0.59-0.97) |
| 1-y mortality | |||||||||
| All transfused patients | 5 334 | 1458 (27.3) | 1.01 (0.96-1.07) | 20 273 | 5 500 (27.1) | 1.00 (ref) | 19 607 | 5 370 (27.4) | 1.05 (1.01-1.09) |
| Patients with known dementia | 109 | 52 (47.7) | 0.97 (0.67-1.40) | 178 | 88 (49.4) | 1.00 (ref) | 87 | 48 (55.2) | 0.95 (0.65-1.38) |
| Patients with known cardiovascular disease | 540 | 199 (36.9) | 1.02 (0.94-1.29) | 1 378 | 426 (30.9) | 1.00 (ref) | 1 075 | 324 (30.1) | 0.92 (0.79-1.06) |
| Patients with known cerebrovascular disease | 393 | 149 (37.9) | 1.05 (0.87-1.26) | 947 | 344 (36.3) | 1.00 (ref) | 590 | 209 (35.4) | 0.90 (0.76-1.07) |
| Red cell recipients | |||||||||
| 30-d mortality | |||||||||
| All transfused patients | 19 828 | 1927 (9.7) | 1.02 (0.97-1.08) | 58 978 | 5 471 (9.3) | 1.00 (ref) | 59 336 | 4 994 (8.4) | 1.00 (0.97-1.04) |
| Patients with known dementia | 858 | 150 (17.5) | 0.95 (0.79-1.13) | 2 229 | 397 (17.8) | 1.00 (ref) | 2 482 | 404 (16.3) | 1.06 (0.83-1.34) |
| Patients with known cardiovascular disease | 1 793 | 297 (16.6) | 1.02 (0.90-1.15) | 6 748 | 1 085 (16.1) | 1.00 (ref) | 7 078 | 1 011 (14.3) | 1.03 (0.88-1.21) |
| Patients with known cerebrovascular disease | 1 296 | 211 (16.3) | 1.05 (0.90-1.21) | 4 673 | 711 (15.2) | 1.00 (ref) | 3 473 | 537 (15.5) | 1.01 (0.91-1.13) |
| 1-y mortality | |||||||||
| All transfused patients | 19 828 | 4885 (24.6) | 1.00 (0.97-1.03) | 58 978 | 14 283 (24.2) | 1.00 (ref) | 57 830 | 13 709 (23.7) | 1.00 (0.97-1.02) |
| Patients with known dementia | 858 | 385 (44.9) | 0.90 (0.81-1.01) | 2 229 | 1 043 (46.8) | 1.00 (ref) | 1 622 | 732 (45.1) | 0.93 (0.85-1.03) |
| Patients with known cardiovascular disease | 1 793 | 602 (33.6) | 1.01 (0.93-1.10) | 6 748 | 2 176 (32.2) | 1.00 (ref) | 5 630 | 1 753 (31.1) | 0.99 (0.94-1.06) |
| Patients with known cerebrovascular disease | 1 296 | 480 (37.0) | 0.99 (0.90-1.09) | 4 673 | 1 713 (36.7) | 1.00 (ref) | 3 473 | 1 297 (37.3) | 1.00 (0.93-1.07) |
| . | Recipients of blood from donors aged <25 y . | Recipients of blood from donors aged 25-50 y . | Recipients of blood from donors aged >50 y . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of patients . | No. of deaths (%) . | HR (95% CI) . | No. of patients . | No. of deaths (%) . | HR (95% CI) . | No. of patients . | No. of deaths (%) . | HR (95% CI) . | |
| Plasma recipients | |||||||||
| 30-d mortality | |||||||||
| All transfused patients | 5 334 | 707 (13.3) | 0.99 (0.91-1.07) | 20 273 | 2 722 (13.4) | 1.00 (ref) | 19 607 | 2 575 (13.1) | 1.01 (0.96-1.07) |
| Patients with known dementia | 109 | 27 (24.8) | 1.22 (0.71-2.09) | 178 | 41 (23.0) | 1.00 (ref) | 87 | 24 (27.6) | 1.05 (0.61-1.80) |
| Patients with known cardiovascular disease | 540 | 118 (21.9) | 1.14 (0.93-1.41) | 1 378 | 240 (17.4) | 1.00 (ref) | 1 075 | 172 (16.0) | 0.93 (0.77-1.12) |
| Patients with known cerebrovascular disease | 393 | 80 (20.4) | 0.99 (0.78-1.27) | 947 | 184 (19.4) | 1.00 (ref) | 590 | 95 (16.1) | 0.76 (0.59-0.97) |
| 1-y mortality | |||||||||
| All transfused patients | 5 334 | 1458 (27.3) | 1.01 (0.96-1.07) | 20 273 | 5 500 (27.1) | 1.00 (ref) | 19 607 | 5 370 (27.4) | 1.05 (1.01-1.09) |
| Patients with known dementia | 109 | 52 (47.7) | 0.97 (0.67-1.40) | 178 | 88 (49.4) | 1.00 (ref) | 87 | 48 (55.2) | 0.95 (0.65-1.38) |
| Patients with known cardiovascular disease | 540 | 199 (36.9) | 1.02 (0.94-1.29) | 1 378 | 426 (30.9) | 1.00 (ref) | 1 075 | 324 (30.1) | 0.92 (0.79-1.06) |
| Patients with known cerebrovascular disease | 393 | 149 (37.9) | 1.05 (0.87-1.26) | 947 | 344 (36.3) | 1.00 (ref) | 590 | 209 (35.4) | 0.90 (0.76-1.07) |
| Red cell recipients | |||||||||
| 30-d mortality | |||||||||
| All transfused patients | 19 828 | 1927 (9.7) | 1.02 (0.97-1.08) | 58 978 | 5 471 (9.3) | 1.00 (ref) | 59 336 | 4 994 (8.4) | 1.00 (0.97-1.04) |
| Patients with known dementia | 858 | 150 (17.5) | 0.95 (0.79-1.13) | 2 229 | 397 (17.8) | 1.00 (ref) | 2 482 | 404 (16.3) | 1.06 (0.83-1.34) |
| Patients with known cardiovascular disease | 1 793 | 297 (16.6) | 1.02 (0.90-1.15) | 6 748 | 1 085 (16.1) | 1.00 (ref) | 7 078 | 1 011 (14.3) | 1.03 (0.88-1.21) |
| Patients with known cerebrovascular disease | 1 296 | 211 (16.3) | 1.05 (0.90-1.21) | 4 673 | 711 (15.2) | 1.00 (ref) | 3 473 | 537 (15.5) | 1.01 (0.91-1.13) |
| 1-y mortality | |||||||||
| All transfused patients | 19 828 | 4885 (24.6) | 1.00 (0.97-1.03) | 58 978 | 14 283 (24.2) | 1.00 (ref) | 57 830 | 13 709 (23.7) | 1.00 (0.97-1.02) |
| Patients with known dementia | 858 | 385 (44.9) | 0.90 (0.81-1.01) | 2 229 | 1 043 (46.8) | 1.00 (ref) | 1 622 | 732 (45.1) | 0.93 (0.85-1.03) |
| Patients with known cardiovascular disease | 1 793 | 602 (33.6) | 1.01 (0.93-1.10) | 6 748 | 2 176 (32.2) | 1.00 (ref) | 5 630 | 1 753 (31.1) | 0.99 (0.94-1.06) |
| Patients with known cerebrovascular disease | 1 296 | 480 (37.0) | 0.99 (0.90-1.09) | 4 673 | 1 713 (36.7) | 1.00 (ref) | 3 473 | 1 297 (37.3) | 1.00 (0.93-1.07) |
Estimates adjusted for age, sex, calendar period, number of transfusions, country, and hospital.
ref, reference.