Characteristics of the study population
| . | Donor age category . | P . | ||
|---|---|---|---|---|
| <25 y . | 25-50 y . | 51-70 y . | ||
| Plasma cohort | ||||
| No. of patients (% of total) | 5 334 (11.7) | 20 723 (45.4) | 19 607 (42.9) | n/a |
| Female sex, N (%) | 2 404 (45.1) | 9 773 (47.2) | 9 151 (46.7) | .01 |
| Median no. of transfusions (range) | 1 (1-6) | 1 (1-6) | 1 (1-5) | 1.00* |
| Patient mean age (SD), y | 59.9 (25.4) | 59.5 (25.5) | 59.1 (25.7) | .06* |
| Country | ||||
| Denmark | 1 374 (25.8) | 5 329 (25.7) | 5 020 (25.6) | 1.00 |
| Sweden | 3 960 (74.2) | 15 394 (74.3) | 14 587 (74.4) | |
| Indication for transfusion | ||||
| Trauma | 732 (13.7) | 2 764 (13.3) | 2 587 (13.2) | .32 |
| Obstetric | 149 (2.8) | 586 (2.8) | 575 (2.9) | |
| Cardiac/vascular surgery | 1 028 (19.3) | 4 085 (19.7) | 3 959 (20.2) | |
| Malignancy surgery | 559 (10.5) | 2 187 (10.6) | 2 064 (10.5) | |
| Other surgery | 1 171 (22.0) | 4 580 (22.1) | 4 341 (22.1) | |
| Hematologic disease | 344 (6.4) | 1 331 (6.4) | 1 258 (6.4) | |
| Other malignant disease | 226 (4.2) | 877 (4.2) | 816 (4.2) | |
| All other indications | 1 125 (21.1) | 4 313 (20.8) | 4 007 (20.4) | |
| Red cell cohort | ||||
| No. of patients (% of total) | 19 828 (14.5) | 58 978 (43.2) | 57 833 (42.3) | n/a |
| Female sex, N (%) | 11 365 (57.3) | 34 007 (57.7) | 33 141 (57.3) | .66 |
| Median no. of transfusions (range) | 1 (1-5) | 1 (1-5) | 1 (1-5) | 1.00* |
| Patient mean age (SD), y | 66.7 (19.6) | 64.0 (24.8) | 62.7 (25.7) | <.0001* |
| Country | ||||
| Denmark | 7 022 (35.4) | 20 894 (35.4) | 20 526 (35.5) | 1.00 |
| Sweden | 12 806 (64.6) | 38 084 (64.6) | 37 307 (64.5) | |
| Indication for transfusion | ||||
| Trauma | 3 548 (17.9) | 10 327 (17.5) | 9 663 (16.7) | <.001 |
| Obstetric | 472 (2.4) | 1 631 (2.8) | 1 751 (3.0) | |
| Cardiac/vascular surgery | 2 545 (12.8) | 7 456 (12.6) | 7 229 (12.5) | |
| Malignancy surgery | 1 765 (8.9) | 5 117 (8.7) | 5 119 (8.9) | |
| Other surgery | 4 434 (22.4) | 12 945 (21.9) | 12 846 (22.2) | |
| Hematologic disease | 1 390 (7.0) | 4 186 (7.1) | 4 288 (7.4) | |
| Other malignant disease | 1 233 (6.2) | 3 664 (6.2) | 3 717 (6.4) | |
| All other indications | 4 441 (22.4) | 13 652 (23.1) | 13 220 (22.9) | |
| . | Donor age category . | P . | ||
|---|---|---|---|---|
| <25 y . | 25-50 y . | 51-70 y . | ||
| Plasma cohort | ||||
| No. of patients (% of total) | 5 334 (11.7) | 20 723 (45.4) | 19 607 (42.9) | n/a |
| Female sex, N (%) | 2 404 (45.1) | 9 773 (47.2) | 9 151 (46.7) | .01 |
| Median no. of transfusions (range) | 1 (1-6) | 1 (1-6) | 1 (1-5) | 1.00* |
| Patient mean age (SD), y | 59.9 (25.4) | 59.5 (25.5) | 59.1 (25.7) | .06* |
| Country | ||||
| Denmark | 1 374 (25.8) | 5 329 (25.7) | 5 020 (25.6) | 1.00 |
| Sweden | 3 960 (74.2) | 15 394 (74.3) | 14 587 (74.4) | |
| Indication for transfusion | ||||
| Trauma | 732 (13.7) | 2 764 (13.3) | 2 587 (13.2) | .32 |
| Obstetric | 149 (2.8) | 586 (2.8) | 575 (2.9) | |
| Cardiac/vascular surgery | 1 028 (19.3) | 4 085 (19.7) | 3 959 (20.2) | |
| Malignancy surgery | 559 (10.5) | 2 187 (10.6) | 2 064 (10.5) | |
| Other surgery | 1 171 (22.0) | 4 580 (22.1) | 4 341 (22.1) | |
| Hematologic disease | 344 (6.4) | 1 331 (6.4) | 1 258 (6.4) | |
| Other malignant disease | 226 (4.2) | 877 (4.2) | 816 (4.2) | |
| All other indications | 1 125 (21.1) | 4 313 (20.8) | 4 007 (20.4) | |
| Red cell cohort | ||||
| No. of patients (% of total) | 19 828 (14.5) | 58 978 (43.2) | 57 833 (42.3) | n/a |
| Female sex, N (%) | 11 365 (57.3) | 34 007 (57.7) | 33 141 (57.3) | .66 |
| Median no. of transfusions (range) | 1 (1-5) | 1 (1-5) | 1 (1-5) | 1.00* |
| Patient mean age (SD), y | 66.7 (19.6) | 64.0 (24.8) | 62.7 (25.7) | <.0001* |
| Country | ||||
| Denmark | 7 022 (35.4) | 20 894 (35.4) | 20 526 (35.5) | 1.00 |
| Sweden | 12 806 (64.6) | 38 084 (64.6) | 37 307 (64.5) | |
| Indication for transfusion | ||||
| Trauma | 3 548 (17.9) | 10 327 (17.5) | 9 663 (16.7) | <.001 |
| Obstetric | 472 (2.4) | 1 631 (2.8) | 1 751 (3.0) | |
| Cardiac/vascular surgery | 2 545 (12.8) | 7 456 (12.6) | 7 229 (12.5) | |
| Malignancy surgery | 1 765 (8.9) | 5 117 (8.7) | 5 119 (8.9) | |
| Other surgery | 4 434 (22.4) | 12 945 (21.9) | 12 846 (22.2) | |
| Hematologic disease | 1 390 (7.0) | 4 186 (7.1) | 4 288 (7.4) | |
| Other malignant disease | 1 233 (6.2) | 3 664 (6.2) | 3 717 (6.4) | |
| All other indications | 4 441 (22.4) | 13 652 (23.1) | 13 220 (22.9) | |
n/a, not applicable.
P values obtained using conditional linear model.