Hematologic laboratory abnormalities
| AE, n (%) . | Prior IMiD . | Prior BTZ + IMiD . | ≥2 prior regimens including BTZ and an IMiD . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PAN-BTZ-Dex (n = 241) . | Pbo-BTZ-Dex (n = 239) . | PAN-BTZ-Dex (n = 92) . | Pbo-BTZ-Dex (n = 99) . | PAN-BTZ-Dex (n = 72) . | Pbo-BTZ-Dex (n = 73) . | |||||||
| All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | |
| Thrombocytopenia | 234 (97) | 162 (67) | 199 (84) | 85 (36) | 89 (97) | 63 (69) | 88 (90) | 47 (48) | 70 (97) | 49 (68) | 65 (90) | 32 (44) |
| Leukopenia | 199 (83) | 57 (24) | 121 (51) | 24 (10) | 77 (84) | 18 (20) | 54 (55) | 12 (12) | 60 (83) | 15 (21) | 40 (55) | 8 (11) |
| Lymphopenia | 202 (84) | 130 (54) | 177 (74) | 97 (41) | 76 (83) | 46 (50) | 74 (75) | 46 (47) | 60 (83) | 35 (49) | 56 (77) | 36 (49) |
| Neutropenia | 193 (80) | 89 (37) | 86 (36) | 30 (13) | 74 (80) | 33 (36) | 45 (46) | 17 (17) | 60 (83) | 29 (40) | 33 (45) | 12 (16) |
| Anemia | 145 (60) | 41 (17) | 133 (56) | 51 (21) | 53 (58) | 17 (19) | 55 (56) | 19 (19) | 42 (58) | 15 (21) | 42 (58) | 15 (21) |
| AE, n (%) . | Prior IMiD . | Prior BTZ + IMiD . | ≥2 prior regimens including BTZ and an IMiD . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PAN-BTZ-Dex (n = 241) . | Pbo-BTZ-Dex (n = 239) . | PAN-BTZ-Dex (n = 92) . | Pbo-BTZ-Dex (n = 99) . | PAN-BTZ-Dex (n = 72) . | Pbo-BTZ-Dex (n = 73) . | |||||||
| All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | All . | Grade 3/4 . | |
| Thrombocytopenia | 234 (97) | 162 (67) | 199 (84) | 85 (36) | 89 (97) | 63 (69) | 88 (90) | 47 (48) | 70 (97) | 49 (68) | 65 (90) | 32 (44) |
| Leukopenia | 199 (83) | 57 (24) | 121 (51) | 24 (10) | 77 (84) | 18 (20) | 54 (55) | 12 (12) | 60 (83) | 15 (21) | 40 (55) | 8 (11) |
| Lymphopenia | 202 (84) | 130 (54) | 177 (74) | 97 (41) | 76 (83) | 46 (50) | 74 (75) | 46 (47) | 60 (83) | 35 (49) | 56 (77) | 36 (49) |
| Neutropenia | 193 (80) | 89 (37) | 86 (36) | 30 (13) | 74 (80) | 33 (36) | 45 (46) | 17 (17) | 60 (83) | 29 (40) | 33 (45) | 12 (16) |
| Anemia | 145 (60) | 41 (17) | 133 (56) | 51 (21) | 53 (58) | 17 (19) | 55 (56) | 19 (19) | 42 (58) | 15 (21) | 42 (58) | 15 (21) |