Table 1 Top SNPs from the discovery... | American Society of Hematology

Table 1

Top SNPs from the discovery cohort validated in replication cohort

RSID	Gene	Risk allele	Discovery MAF cases	Discovery MAF controls	Discovery cohort P*	Discovery cohort HR (95% CI)	Replication cohort P†
rs79085477	BMP7	T	0.03	0	5.34 × 10⁻⁸	15.0 (5.64-39.7)	.0498
rs75161997	BMP7	T	0.03	0	5.34 × 10⁻⁸	15.0 (5.64-39.7)	.0498
rs1891059	PROX1-AS1	A	0.061	0.017	2.28 × 10⁻⁷	6.48 (3.19-13.2)	.008
rs115602884		T
rs74533616		T
rs141059755	LINC00251	G	0.018	0.002	8.48 × 10⁻⁷	23.3 (6.65-81.5)	.003
rs80223967	PROX1-AS1	G	0.061	0.019	6.63 × 10⁻⁷	6.1 (2.99-12.4)	.01
rs17021408	PROX1-AS1	C	0.061	0.023	1.01 × 10⁻⁶	5.89 (2.89-12.0)	.01
rs61818937	PROX1-AS1	A	0.061	0.023	1.01 × 10⁻⁶	5.89 (2.89-12.0)	.01
rs117532069	DOK5	A	0.018	0.0017	1.71 × 10⁻⁶	21.0 (6.03-72.9)	.003

RSID	Gene	Risk allele	Discovery MAF cases	Discovery MAF controls	Discovery cohort P*	Discovery cohort HR (95% CI)	Replication cohort P†
rs79085477	BMP7	T	0.03	0	5.34 × 10⁻⁸	15.0 (5.64-39.7)	.0498
rs75161997	BMP7	T	0.03	0	5.34 × 10⁻⁸	15.0 (5.64-39.7)	.0498
rs1891059	PROX1-AS1	A	0.061	0.017	2.28 × 10⁻⁷	6.48 (3.19-13.2)	.008
rs115602884		T
rs74533616		T
rs141059755	LINC00251	G	0.018	0.002	8.48 × 10⁻⁷	23.3 (6.65-81.5)	.003
rs80223967	PROX1-AS1	G	0.061	0.019	6.63 × 10⁻⁷	6.1 (2.99-12.4)	.01
rs17021408	PROX1-AS1	C	0.061	0.023	1.01 × 10⁻⁶	5.89 (2.89-12.0)	.01
rs61818937	PROX1-AS1	A	0.061	0.023	1.01 × 10⁻⁶	5.89 (2.89-12.0)	.01
rs117532069	DOK5	A	0.018	0.0017	1.71 × 10⁻⁶	21.0 (6.03-72.9)	.003

P value for association of SNP genotype with osteonecrosis risk in discovery cohort (N = 369).

P value for association of SNP genotype with osteonecrosis in the replication cohort (N = 817).