Table 1 Clinical and pathologic... | American Society of Hematology

Table 1

Clinical and pathologic characteristics of study patients

Patient no.	Age (y)/ sex	MYD88 L265P mutation	Organs involved	2012 Revised Mayo AL amyloidosis stage†	Monoclonal protein in serum		Urine total protein (g/24 h)	Clonal cells in bone marrow*	OS from diagnosis (mo)	Progression
Patient no.	Age (y)/ sex	MYD88 L265P mutation	Organs involved	2012 Revised Mayo AL amyloidosis stage†	Isotype	g/dL	Urine total protein (g/24 h)	Clonal cells in bone marrow*	OS from diagnosis (mo)	Y/N	PFS (mo)
1	68/F	Positive	Peripheral nervous system	II	IgM λ	2.4	0.05	Clonal B lymphocytes and clonal plasma cells	109	Y	76
2	70/M	Positive	Peripheral and autonomic nervous system	I	IgM λ	0.9	0.98	Clonal B lymphocytes and clonal plasma cells	43	N	43
3	63/F	Positive	Spleen and kidney	I	IgM λ‡ IgA λ	0.3	8.87	Clonal plasma cells	83	Y	28
4	52/M	Positive	Peripheral and central nervous system	I	IgM κ	0.5	0.08	Clonal B lymphocytes	78‡	Y	67
5	48/F	Positive	Kidney and autonomic nervous system	II	IgM κ	1.5	3.65	Clonal B lymphocytes and clonal plasma cells	62‡	Y	48
6	65/M	Positive	Lungs and lymph node	I	IgM λ	1.4	0.06	Clonal B lymphocytes	41‡	Y	33
7	56/M	Positive	Lymph nodes and soft tissue	I	IgM κ	1.6	0.12	Clonal plasma cells and clonal B lymphocytes	26	N	26
8	65/M	Positive	Kidney	I	IgM κ	2.4	9.59	Clonal plasma cells and clonal B lymphocytes	30‡	N	30
9	60/M	Positive	Kidney	I	IgM κ‡ IgM λ	1.1	1.66	Clonal plasma cells and clonal B lymphocytes	12‡	N	12
10	60/M	Positive	Heart and tongue	III	IgM κ	1.1	0.07	Clonal B lymphocytes and clonal plasma cells	21	N	21
11	62/F	Negative	Kidney	I	IgM κ	0.6	5.90	Clonal plasma cells	104‡	N	104
12	53/M	Negative	Kidney, heart and gastrointestinal tract	III	IgM κ	0.1	34.9	Clonal plasma cells	16	Y	14
13	60/M	Negative	Heart, lymph nodes, and tongue	II	IgM κ‡ IgM λ	0.5	0.20	Clonal plasma cells	120‡	N	120
14	56/M	Negative	Kidney	I	IgM λ	0.9	6.19	Clonal plasma cells and clonal B lymphocytes	55‡	N	55

Patient no.	Age (y)/ sex	MYD88 L265P mutation	Organs involved	2012 Revised Mayo AL amyloidosis stage†	Monoclonal protein in serum		Urine total protein (g/24 h)	Clonal cells in bone marrow*	OS from diagnosis (mo)	Progression
Patient no.	Age (y)/ sex	MYD88 L265P mutation	Organs involved	2012 Revised Mayo AL amyloidosis stage†	Isotype	g/dL	Urine total protein (g/24 h)	Clonal cells in bone marrow*	OS from diagnosis (mo)	Y/N	PFS (mo)
1	68/F	Positive	Peripheral nervous system	II	IgM λ	2.4	0.05	Clonal B lymphocytes and clonal plasma cells	109	Y	76
2	70/M	Positive	Peripheral and autonomic nervous system	I	IgM λ	0.9	0.98	Clonal B lymphocytes and clonal plasma cells	43	N	43
3	63/F	Positive	Spleen and kidney	I	IgM λ‡ IgA λ	0.3	8.87	Clonal plasma cells	83	Y	28
4	52/M	Positive	Peripheral and central nervous system	I	IgM κ	0.5	0.08	Clonal B lymphocytes	78‡	Y	67
5	48/F	Positive	Kidney and autonomic nervous system	II	IgM κ	1.5	3.65	Clonal B lymphocytes and clonal plasma cells	62‡	Y	48
6	65/M	Positive	Lungs and lymph node	I	IgM λ	1.4	0.06	Clonal B lymphocytes	41‡	Y	33
7	56/M	Positive	Lymph nodes and soft tissue	I	IgM κ	1.6	0.12	Clonal plasma cells and clonal B lymphocytes	26	N	26
8	65/M	Positive	Kidney	I	IgM κ	2.4	9.59	Clonal plasma cells and clonal B lymphocytes	30‡	N	30
9	60/M	Positive	Kidney	I	IgM κ‡ IgM λ	1.1	1.66	Clonal plasma cells and clonal B lymphocytes	12‡	N	12
10	60/M	Positive	Heart and tongue	III	IgM κ	1.1	0.07	Clonal B lymphocytes and clonal plasma cells	21	N	21
11	62/F	Negative	Kidney	I	IgM κ	0.6	5.90	Clonal plasma cells	104‡	N	104
12	53/M	Negative	Kidney, heart and gastrointestinal tract	III	IgM κ	0.1	34.9	Clonal plasma cells	16	Y	14
13	60/M	Negative	Heart, lymph nodes, and tongue	II	IgM κ‡ IgM λ	0.5	0.20	Clonal plasma cells	120‡	N	120
14	56/M	Negative	Kidney	I	IgM λ	0.9	6.19	Clonal plasma cells and clonal B lymphocytes	55‡	N	55

F, female; M, male.

Clonality was assessed by immunohistochemistry and flow cytometry from bone marrow specimens.

†

Calculated using serum troponin T, N-terminal pro–brain natriuretic peptide, and difference between involved and uninvolved free light chains.

‡

Patients alive.

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