Clinical and pathologic characteristics of study patients
Patient no. . | Age (y)/ sex . | MYD88 L265P mutation . | Organs involved . | 2012 Revised Mayo AL amyloidosis stage† . | Monoclonal protein in serum . | Urine total protein (g/24 h) . | Clonal cells in bone marrow* . | OS from diagnosis (mo) . | Progression . | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Isotype . | g/dL . | Y/N . | PFS (mo) . | ||||||||
1 | 68/F | Positive | Peripheral nervous system | II | IgM λ | 2.4 | 0.05 | Clonal B lymphocytes and clonal plasma cells | 109 | Y | 76 |
2 | 70/M | Positive | Peripheral and autonomic nervous system | I | IgM λ | 0.9 | 0.98 | Clonal B lymphocytes and clonal plasma cells | 43 | N | 43 |
3 | 63/F | Positive | Spleen and kidney | I | IgM λ‡ IgA λ | 0.3 | 8.87 | Clonal plasma cells | 83 | Y | 28 |
4 | 52/M | Positive | Peripheral and central nervous system | I | IgM κ | 0.5 | 0.08 | Clonal B lymphocytes | 78‡ | Y | 67 |
5 | 48/F | Positive | Kidney and autonomic nervous system | II | IgM κ | 1.5 | 3.65 | Clonal B lymphocytes and clonal plasma cells | 62‡ | Y | 48 |
6 | 65/M | Positive | Lungs and lymph node | I | IgM λ | 1.4 | 0.06 | Clonal B lymphocytes | 41‡ | Y | 33 |
7 | 56/M | Positive | Lymph nodes and soft tissue | I | IgM κ | 1.6 | 0.12 | Clonal plasma cells and clonal B lymphocytes | 26 | N | 26 |
8 | 65/M | Positive | Kidney | I | IgM κ | 2.4 | 9.59 | Clonal plasma cells and clonal B lymphocytes | 30‡ | N | 30 |
9 | 60/M | Positive | Kidney | I | IgM κ‡ IgM λ | 1.1 | 1.66 | Clonal plasma cells and clonal B lymphocytes | 12‡ | N | 12 |
10 | 60/M | Positive | Heart and tongue | III | IgM κ | 1.1 | 0.07 | Clonal B lymphocytes and clonal plasma cells | 21 | N | 21 |
11 | 62/F | Negative | Kidney | I | IgM κ | 0.6 | 5.90 | Clonal plasma cells | 104‡ | N | 104 |
12 | 53/M | Negative | Kidney, heart and gastrointestinal tract | III | IgM κ | 0.1 | 34.9 | Clonal plasma cells | 16 | Y | 14 |
13 | 60/M | Negative | Heart, lymph nodes, and tongue | II | IgM κ‡ IgM λ | 0.5 | 0.20 | Clonal plasma cells | 120‡ | N | 120 |
14 | 56/M | Negative | Kidney | I | IgM λ | 0.9 | 6.19 | Clonal plasma cells and clonal B lymphocytes | 55‡ | N | 55 |
Patient no. . | Age (y)/ sex . | MYD88 L265P mutation . | Organs involved . | 2012 Revised Mayo AL amyloidosis stage† . | Monoclonal protein in serum . | Urine total protein (g/24 h) . | Clonal cells in bone marrow* . | OS from diagnosis (mo) . | Progression . | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Isotype . | g/dL . | Y/N . | PFS (mo) . | ||||||||
1 | 68/F | Positive | Peripheral nervous system | II | IgM λ | 2.4 | 0.05 | Clonal B lymphocytes and clonal plasma cells | 109 | Y | 76 |
2 | 70/M | Positive | Peripheral and autonomic nervous system | I | IgM λ | 0.9 | 0.98 | Clonal B lymphocytes and clonal plasma cells | 43 | N | 43 |
3 | 63/F | Positive | Spleen and kidney | I | IgM λ‡ IgA λ | 0.3 | 8.87 | Clonal plasma cells | 83 | Y | 28 |
4 | 52/M | Positive | Peripheral and central nervous system | I | IgM κ | 0.5 | 0.08 | Clonal B lymphocytes | 78‡ | Y | 67 |
5 | 48/F | Positive | Kidney and autonomic nervous system | II | IgM κ | 1.5 | 3.65 | Clonal B lymphocytes and clonal plasma cells | 62‡ | Y | 48 |
6 | 65/M | Positive | Lungs and lymph node | I | IgM λ | 1.4 | 0.06 | Clonal B lymphocytes | 41‡ | Y | 33 |
7 | 56/M | Positive | Lymph nodes and soft tissue | I | IgM κ | 1.6 | 0.12 | Clonal plasma cells and clonal B lymphocytes | 26 | N | 26 |
8 | 65/M | Positive | Kidney | I | IgM κ | 2.4 | 9.59 | Clonal plasma cells and clonal B lymphocytes | 30‡ | N | 30 |
9 | 60/M | Positive | Kidney | I | IgM κ‡ IgM λ | 1.1 | 1.66 | Clonal plasma cells and clonal B lymphocytes | 12‡ | N | 12 |
10 | 60/M | Positive | Heart and tongue | III | IgM κ | 1.1 | 0.07 | Clonal B lymphocytes and clonal plasma cells | 21 | N | 21 |
11 | 62/F | Negative | Kidney | I | IgM κ | 0.6 | 5.90 | Clonal plasma cells | 104‡ | N | 104 |
12 | 53/M | Negative | Kidney, heart and gastrointestinal tract | III | IgM κ | 0.1 | 34.9 | Clonal plasma cells | 16 | Y | 14 |
13 | 60/M | Negative | Heart, lymph nodes, and tongue | II | IgM κ‡ IgM λ | 0.5 | 0.20 | Clonal plasma cells | 120‡ | N | 120 |
14 | 56/M | Negative | Kidney | I | IgM λ | 0.9 | 6.19 | Clonal plasma cells and clonal B lymphocytes | 55‡ | N | 55 |