Table 3 Treatment with LCP4 depletes... | American Society of Hematology

Table 3

Treatment with LCP4 depletes JAK2V617F⁺ MF NSG NRCs

Patient #	JAK2V617F Allele Burden in BM hCD45⁺ cells (%)		% Reduction*
Patient #	CD34⁺ cells treated with cytokines alone	CD34⁺ cells treated with cytokines + LCP4 (100 nM)	% Reduction*
SP10	77.0	47.1	38.8
SP19	76.7	65.9	14.1
SP21	26.2	7.3	72.1
SP22	51.3	38.1	25.7

Patient #	JAK2V617F Allele Burden in BM hCD45⁺ cells (%)		% Reduction*
Patient #	CD34⁺ cells treated with cytokines alone	CD34⁺ cells treated with cytokines + LCP4 (100 nM)	% Reduction*
SP10	77.0	47.1	38.8
SP19	76.7	65.9	14.1
SP21	26.2	7.3	72.1
SP22	51.3	38.1	25.7

Percent reduction in column 4 is calculated by (JAK2V617F allele burden shown in column 2 − JAK2V617F allele burden shown in column 3) / JAK2V617F allele burden shown in column 2 for individual patient.

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