Table 3

Replication set univariate analysis for candidate biomarkers

Candidate biomarkersNo. of evaluable casesEffect size*PROC AUC
Replication set 1     
 Aminopeptidase N (sCD13) 193 1.0× .99  
 sIL-2Rα 198 1.1× .13 0.56 
 sBAFF 198 1.2× .05 0.59 
 CXCL10 198 1.5× .02 0.61 
 PI-16 173 0.9× .30  
 ICAM-1 198 1.2× .01 0.60 
 CXCL9 187 1.4× .06 0.60 
 Anti-LG3† 198 0.7× .04 0.59 
 Endothelin-1† 160 1.3× .20  
 Gelsolin† 173 1.0× .43  
 Kallikrein† 173 1.0× .48  
Combination of markers     
 CXCL10 + anti-LG3 198  .003 0.65 
 CXCL10 + CXCL9 + sBAFF + anti-LG3 187  .04 0.63 
Replication set 2     
 Aminopeptidase N (sCD13) 83 1.3× .02 0.64 
 sIL-2Rα 83 1.1× .28  
 sBAFF 83 1.5× .01 0.68 
 CXCL10 83 3.9× <.0001 0.78 
 PI-16 83 0.8× .11  
 ICAM-1 83 1.2× .23  
 CXCL9 83 1.8× .04 0.67 
 Anti-LG3‡ 83 0.9× .55  
 Endothelin-1 80 0.7× .02 0.65 
 Gelsolin† 83 0.8× .0007 0.71 
 Kallikrein† 83 1.0× .58  
Combination of markers     
 CXCL10 + CXCL9 83  <.0001 0.83 
 CXCL10 + CXCL9 + sBAFF + anti-LG3 83  <.0001 0.83 
Candidate biomarkersNo. of evaluable casesEffect size*PROC AUC
Replication set 1     
 Aminopeptidase N (sCD13) 193 1.0× .99  
 sIL-2Rα 198 1.1× .13 0.56 
 sBAFF 198 1.2× .05 0.59 
 CXCL10 198 1.5× .02 0.61 
 PI-16 173 0.9× .30  
 ICAM-1 198 1.2× .01 0.60 
 CXCL9 187 1.4× .06 0.60 
 Anti-LG3† 198 0.7× .04 0.59 
 Endothelin-1† 160 1.3× .20  
 Gelsolin† 173 1.0× .43  
 Kallikrein† 173 1.0× .48  
Combination of markers     
 CXCL10 + anti-LG3 198  .003 0.65 
 CXCL10 + CXCL9 + sBAFF + anti-LG3 187  .04 0.63 
Replication set 2     
 Aminopeptidase N (sCD13) 83 1.3× .02 0.64 
 sIL-2Rα 83 1.1× .28  
 sBAFF 83 1.5× .01 0.68 
 CXCL10 83 3.9× <.0001 0.78 
 PI-16 83 0.8× .11  
 ICAM-1 83 1.2× .23  
 CXCL9 83 1.8× .04 0.67 
 Anti-LG3‡ 83 0.9× .55  
 Endothelin-1 80 0.7× .02 0.65 
 Gelsolin† 83 0.8× .0007 0.71 
 Kallikrein† 83 1.0× .58  
Combination of markers     
 CXCL10 + CXCL9 83  <.0001 0.83 
 CXCL10 + CXCL9 + sBAFF + anti-LG3 83  <.0001 0.83 
*

Fold difference for cGVHD vs control.

†

Considered to be vascular markers.

‡

Anti-LG3 has been associated with renal transplant rejection; reagents for anti-LG3 ELISA were provided by M.-J.H.

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