Table 2 Test set univariate analysis... | American Society of Hematology

Table 2

Test set univariate analysis results

Candidate biomarkers	Method of measurement	cGVHD cases (n = 17)		Controls (n = 21)		Effect size*	P
Candidate biomarkers	Method of measurement	Mean	SD	Mean	SD	Effect size*	P
Test set 1
Aminopeptidase N (sCD13), μU/mL	Enzymatic assay	0.30	0.14	0.18	0.07	1.5×	.004
	Proteomic	1.44	0.73	0.90	0.26	1.5×	.004
IL-2Rα (sCD25) (pg/mL)	Luminex	3125	1825	1580	700	1.8×	.005
PI-16, fmol	Proteomic	0.81	0.27	1.12	0.35	0.7×	.005
	MRM-MS	1.21	0.56	1.63	0.47	0.5×	.005
Gelsolin, fmol	Proteomic	0.92	0.22	1.11	0.19	0.8×	.02
	MRM-MS	0.063	0.040	0.133	0.090	0.7×	.02
Kallikrein, fmol	Proteomic	0.80	0.32	1.00	0.32	0.8×	.06
	MRM-MS	0.068	0.022	0.095	0.043	0.8×	.007
ICAM-1, pg/mL	Luminex	140	110	80	40	1.4×	.04
Test set 2		(n = 19)		(n = 4)
CXCL10, pg/mL	ELISA	1423	765	349	157	3.8×	.005

Candidate biomarkers	Method of measurement	cGVHD cases (n = 17)		Controls (n = 21)		Effect size*	P
Candidate biomarkers	Method of measurement	Mean	SD	Mean	SD	Effect size*	P
Test set 1
Aminopeptidase N (sCD13), μU/mL	Enzymatic assay	0.30	0.14	0.18	0.07	1.5×	.004
	Proteomic	1.44	0.73	0.90	0.26	1.5×	.004
IL-2Rα (sCD25) (pg/mL)	Luminex	3125	1825	1580	700	1.8×	.005
PI-16, fmol	Proteomic	0.81	0.27	1.12	0.35	0.7×	.005
	MRM-MS	1.21	0.56	1.63	0.47	0.5×	.005
Gelsolin, fmol	Proteomic	0.92	0.22	1.11	0.19	0.8×	.02
	MRM-MS	0.063	0.040	0.133	0.090	0.7×	.02
Kallikrein, fmol	Proteomic	0.80	0.32	1.00	0.32	0.8×	.06
	MRM-MS	0.068	0.022	0.095	0.043	0.8×	.007
ICAM-1, pg/mL	Luminex	140	110	80	40	1.4×	.04
Test set 2		(n = 19)		(n = 4)
CXCL10, pg/mL	ELISA	1423	765	349	157	3.8×	.005

SD, standard deviation; U, enzymatic unit.

Fold difference for cGVHD vs control.