2016 WHO classification of mature lymphoid, histiocytic, and dendritic neoplasms
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| Monoclonal B-cell lymphocytosis* |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic B-cell lymphoma/leukemia, unclassifiable |
| Splenic diffuse red pulp small B-cell lymphoma |
| Hairy cell leukemia-variant |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Monoclonal gammopathy of undetermined significance (MGUS), IgM* |
| μ heavy-chain disease |
| γ heavy-chain disease |
| α heavy-chain disease |
| Monoclonal gammopathy of undetermined significance (MGUS), IgG/A* |
| Plasma cell myeloma |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Monoclonal immunoglobulin deposition diseases* |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma |
| Follicular lymphoma |
| In situ follicular neoplasia* |
| Duodenal-type follicular lymphoma* |
| Pediatric-type follicular lymphoma* |
| Large B-cell lymphoma with IRF4 rearrangement* |
| Primary cutaneous follicle center lymphoma |
| Mantle cell lymphoma |
| In situ mantle cell neoplasia* |
| Diffuse large B-cell lymphoma (DLBCL), NOS |
| Germinal center B-cell type* |
| Activated B-cell type* |
| T-cell/histiocyte-rich large B-cell lymphoma |
| Primary DLBCL of the central nervous system (CNS) |
| Primary cutaneous DLBCL, leg type |
| EBV+ DLBCL, NOS* |
| EBV+mucocutaneous ulcer* |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| ALK+ large B-cell lymphoma |
| Plasmablastic lymphoma |
| Primary effusion lymphoma |
| HHV8+DLBCL, NOS* |
| Burkitt lymphoma |
| Burkitt-like lymphoma with 11q aberration* |
| High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements* |
| High-grade B-cell lymphoma, NOS* |
| B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma |
| Mature T and NK neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells |
| Aggressive NK-cell leukemia |
| Systemic EBV+ T-cell lymphoma of childhood* |
| Hydroa vacciniforme–like lymphoproliferative disorder* |
| Adult T-cell leukemia/lymphoma |
| Extranodal NK-/T-cell lymphoma, nasal type |
| Enteropathy-associated T-cell lymphoma |
| Monomorphic epitheliotropic intestinal T-cell lymphoma* |
| Indolent T-cell lymphoproliferative disorder of the GI tract* |
| Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous γδ T-cell lymphoma |
| Primary cutaneous CD8+aggressive epidermotropic cytotoxic T-cell lymphoma |
| Primary cutaneous acral CD8+T-cell lymphoma* |
| Primary cutaneous CD4+small/medium T-cell lymphoproliferative disorder* |
| Peripheral T-cell lymphoma, NOS |
| Angioimmunoblastic T-cell lymphoma |
| Follicular T-cell lymphoma* |
| Nodal peripheral T-cell lymphoma with TFH phenotype* |
| Anaplastic large-cell lymphoma, ALK+ |
| Anaplastic large-cell lymphoma, ALK−* |
| Breast implant–associated anaplastic large-cell lymphoma* |
| Hodgkin lymphoma |
| Nodular lymphocyte predominant Hodgkin lymphoma |
| Classical Hodgkin lymphoma |
| Nodular sclerosis classical Hodgkin lymphoma |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity classical Hodgkin lymphoma |
| Lymphocyte-depleted classical Hodgkin lymphoma |
| Posttransplant lymphoproliferative disorders (PTLD) |
| Plasmacytic hyperplasia PTLD |
| Infectious mononucleosis PTLD |
| Florid follicular hyperplasia PTLD* |
| Polymorphic PTLD |
| Monomorphic PTLD (B- and T-/NK-cell types) |
| Classical Hodgkin lymphoma PTLD |
| Histiocytic and dendritic cell neoplasms |
| Histiocytic sarcoma |
| Langerhans cell histiocytosis |
| Langerhans cell sarcoma |
| Indeterminate dendritic cell tumor |
| Interdigitating dendritic cell sarcoma |
| Follicular dendritic cell sarcoma |
| Fibroblastic reticular cell tumor |
| Disseminated juvenile xanthogranuloma |
| Erdheim-Chester disease* |
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| Monoclonal B-cell lymphocytosis* |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic B-cell lymphoma/leukemia, unclassifiable |
| Splenic diffuse red pulp small B-cell lymphoma |
| Hairy cell leukemia-variant |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Monoclonal gammopathy of undetermined significance (MGUS), IgM* |
| μ heavy-chain disease |
| γ heavy-chain disease |
| α heavy-chain disease |
| Monoclonal gammopathy of undetermined significance (MGUS), IgG/A* |
| Plasma cell myeloma |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Monoclonal immunoglobulin deposition diseases* |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma |
| Follicular lymphoma |
| In situ follicular neoplasia* |
| Duodenal-type follicular lymphoma* |
| Pediatric-type follicular lymphoma* |
| Large B-cell lymphoma with IRF4 rearrangement* |
| Primary cutaneous follicle center lymphoma |
| Mantle cell lymphoma |
| In situ mantle cell neoplasia* |
| Diffuse large B-cell lymphoma (DLBCL), NOS |
| Germinal center B-cell type* |
| Activated B-cell type* |
| T-cell/histiocyte-rich large B-cell lymphoma |
| Primary DLBCL of the central nervous system (CNS) |
| Primary cutaneous DLBCL, leg type |
| EBV+ DLBCL, NOS* |
| EBV+mucocutaneous ulcer* |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| ALK+ large B-cell lymphoma |
| Plasmablastic lymphoma |
| Primary effusion lymphoma |
| HHV8+DLBCL, NOS* |
| Burkitt lymphoma |
| Burkitt-like lymphoma with 11q aberration* |
| High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements* |
| High-grade B-cell lymphoma, NOS* |
| B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma |
| Mature T and NK neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells |
| Aggressive NK-cell leukemia |
| Systemic EBV+ T-cell lymphoma of childhood* |
| Hydroa vacciniforme–like lymphoproliferative disorder* |
| Adult T-cell leukemia/lymphoma |
| Extranodal NK-/T-cell lymphoma, nasal type |
| Enteropathy-associated T-cell lymphoma |
| Monomorphic epitheliotropic intestinal T-cell lymphoma* |
| Indolent T-cell lymphoproliferative disorder of the GI tract* |
| Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous γδ T-cell lymphoma |
| Primary cutaneous CD8+aggressive epidermotropic cytotoxic T-cell lymphoma |
| Primary cutaneous acral CD8+T-cell lymphoma* |
| Primary cutaneous CD4+small/medium T-cell lymphoproliferative disorder* |
| Peripheral T-cell lymphoma, NOS |
| Angioimmunoblastic T-cell lymphoma |
| Follicular T-cell lymphoma* |
| Nodal peripheral T-cell lymphoma with TFH phenotype* |
| Anaplastic large-cell lymphoma, ALK+ |
| Anaplastic large-cell lymphoma, ALK−* |
| Breast implant–associated anaplastic large-cell lymphoma* |
| Hodgkin lymphoma |
| Nodular lymphocyte predominant Hodgkin lymphoma |
| Classical Hodgkin lymphoma |
| Nodular sclerosis classical Hodgkin lymphoma |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity classical Hodgkin lymphoma |
| Lymphocyte-depleted classical Hodgkin lymphoma |
| Posttransplant lymphoproliferative disorders (PTLD) |
| Plasmacytic hyperplasia PTLD |
| Infectious mononucleosis PTLD |
| Florid follicular hyperplasia PTLD* |
| Polymorphic PTLD |
| Monomorphic PTLD (B- and T-/NK-cell types) |
| Classical Hodgkin lymphoma PTLD |
| Histiocytic and dendritic cell neoplasms |
| Histiocytic sarcoma |
| Langerhans cell histiocytosis |
| Langerhans cell sarcoma |
| Indeterminate dendritic cell tumor |
| Interdigitating dendritic cell sarcoma |
| Follicular dendritic cell sarcoma |
| Fibroblastic reticular cell tumor |
| Disseminated juvenile xanthogranuloma |
| Erdheim-Chester disease* |
Provisional entities are listed in italics.
Changes from the 2008 classification.