Factors associated with overall response, PFS, and OS
| . | Overall response . | PFS . | OS . | |||
|---|---|---|---|---|---|---|
| Unadjusted [OR (95% CI)] . | Adjusted [OR (95% CI)] . | Unadjusted [HR (95% CI)] . | Adjusted [HR (95% CI)] . | Unadjusted [HR (95% CI)] . | Adjusted [HR (95% CI)] . | |
| Age (in 10-year increments) | 1.16 (0.64-2.11) | 1.22 (0.62-2.40) | 0.80 (0.59-1.10) | 0.72 (0.50-1.04) | 0.83 (0.56-1.24) | 0.88 (0.51-1.49) |
| Number of prior therapies (≥5 vs <5) | 1.23 (0.47-3.21) | 1.77 (0.56-5.60) | 0.79 (0.47-1.33) | 0.54 (0.29-0.99)* | 0.94 (0.48-1.85) | 0.66 (0.32-1.38) |
| B2-microglobulin (mg/L) | 1.03 (0.84-1.25) | 0.99 (0.80-1.23) | 1.09 (0.99-1.20) | 1.15 (1.03-1.28)* | 1.30 (1.15-1.47)* | 1.38 (1.21-1.58)* |
| High-risk cytogenetics | 0.36 (0.11-1.22) | 0.33 (0.09-1.22) | 1.73 (0.92-3.27) | 1.77 (0.88-3.55) | 2.12 (1.00-4.48) | 2.21 (0.98-4.98) |
| Study arm* (arm C vs B) | 2.88 (1.09-7.61)* | 2.98 (0.99-8.99) | 0.66 (0.40-1.10) | 0.54 (0.29-1.00)* | 0.63 (0.32-1.22) | 0.54 (0.25-1.17) |
| . | Overall response . | PFS . | OS . | |||
|---|---|---|---|---|---|---|
| Unadjusted [OR (95% CI)] . | Adjusted [OR (95% CI)] . | Unadjusted [HR (95% CI)] . | Adjusted [HR (95% CI)] . | Unadjusted [HR (95% CI)] . | Adjusted [HR (95% CI)] . | |
| Age (in 10-year increments) | 1.16 (0.64-2.11) | 1.22 (0.62-2.40) | 0.80 (0.59-1.10) | 0.72 (0.50-1.04) | 0.83 (0.56-1.24) | 0.88 (0.51-1.49) |
| Number of prior therapies (≥5 vs <5) | 1.23 (0.47-3.21) | 1.77 (0.56-5.60) | 0.79 (0.47-1.33) | 0.54 (0.29-0.99)* | 0.94 (0.48-1.85) | 0.66 (0.32-1.38) |
| B2-microglobulin (mg/L) | 1.03 (0.84-1.25) | 0.99 (0.80-1.23) | 1.09 (0.99-1.20) | 1.15 (1.03-1.28)* | 1.30 (1.15-1.47)* | 1.38 (1.21-1.58)* |
| High-risk cytogenetics | 0.36 (0.11-1.22) | 0.33 (0.09-1.22) | 1.73 (0.92-3.27) | 1.77 (0.88-3.55) | 2.12 (1.00-4.48) | 2.21 (0.98-4.98) |
| Study arm* (arm C vs B) | 2.88 (1.09-7.61)* | 2.98 (0.99-8.99) | 0.66 (0.40-1.10) | 0.54 (0.29-1.00)* | 0.63 (0.32-1.22) | 0.54 (0.25-1.17) |
HR, hazard ratio; OR, odds ratio.
Overall response is defined as partial response or better; study arm P = .052 in the multivariable overall response model. *P < .05.