All-cause, all-grade nonhematologic adverse events in >15% of patients regardless of attribution
| Adverse event . | Grade . | Arm B (N = 35) [N (%)] . | Arm C (N = 33) [N (%)] . | P value* . |
|---|---|---|---|---|
| Anemia | 1/2 | 12 (34.3) | 9 (27.3) | .6049 |
| Constipation | 1/2 | 8 (22.9) | 6 (18.2) | .7669 |
| Diarrhea | 1/2 | 6 (17.1) | 9 (27.3) | .3866 |
| Nausea | 1/2 | 6 (17.1) | 9 (27.3) | .3866 |
| Edema | 1/2 | 4 (11.4) | 6 (18.2) | .5066 |
| Fatigue | 1/2 | 9 (25.7) | 3 (9.1) | .1114 |
| Fever | 1/2 | 6 (17.1) | 4 (12.1) | .7350 |
| Pain | 1/2 | 2 (5.7) | 10 (30.3) | .0105 |
| Thrombocytopenia | 1/2 | 8 (22.9) | 11 (33.3) | .4209 |
| Generalized muscle weakness | 1/2 | 7 (20) | 2 (6.1) | .1515 |
| Peripheral sensory neuropathy | 1/2 | 6 (17.1) | 4 (12.1) | .7350 |
| Tremor | 1/2 | 7 (20) | 5 (15.2) | .7531 |
| Dyspnea | 1/2 | 5 (14.3) | 5 (15.2) | 1.0000 |
| Skin / subcutaneous tissue disorders | 1/2 | 2 (5.7) | 5 (15.2) | .2522 |
| Anemia | 3/4/5 | 4 (11.4) | 9 (27.3) | .1277 |
| Lung infection | 3/4/5 | 6 (17.1) | 3 (9.1) | .4783 |
| Neutropenia | 3/4/5 | 11 (31.4) | 17 (51.5) | .1389 |
| Thrombocytopenia | 3/4/5 | 2 (5.7) | 5 (15.2) | .2522 |
| Hyperglycemia | 3/4/5 | 1 (2.9) | 6 (18.2) | .0513 |
| Adverse event . | Grade . | Arm B (N = 35) [N (%)] . | Arm C (N = 33) [N (%)] . | P value* . |
|---|---|---|---|---|
| Anemia | 1/2 | 12 (34.3) | 9 (27.3) | .6049 |
| Constipation | 1/2 | 8 (22.9) | 6 (18.2) | .7669 |
| Diarrhea | 1/2 | 6 (17.1) | 9 (27.3) | .3866 |
| Nausea | 1/2 | 6 (17.1) | 9 (27.3) | .3866 |
| Edema | 1/2 | 4 (11.4) | 6 (18.2) | .5066 |
| Fatigue | 1/2 | 9 (25.7) | 3 (9.1) | .1114 |
| Fever | 1/2 | 6 (17.1) | 4 (12.1) | .7350 |
| Pain | 1/2 | 2 (5.7) | 10 (30.3) | .0105 |
| Thrombocytopenia | 1/2 | 8 (22.9) | 11 (33.3) | .4209 |
| Generalized muscle weakness | 1/2 | 7 (20) | 2 (6.1) | .1515 |
| Peripheral sensory neuropathy | 1/2 | 6 (17.1) | 4 (12.1) | .7350 |
| Tremor | 1/2 | 7 (20) | 5 (15.2) | .7531 |
| Dyspnea | 1/2 | 5 (14.3) | 5 (15.2) | 1.0000 |
| Skin / subcutaneous tissue disorders | 1/2 | 2 (5.7) | 5 (15.2) | .2522 |
| Anemia | 3/4/5 | 4 (11.4) | 9 (27.3) | .1277 |
| Lung infection | 3/4/5 | 6 (17.1) | 3 (9.1) | .4783 |
| Neutropenia | 3/4/5 | 11 (31.4) | 17 (51.5) | .1389 |
| Thrombocytopenia | 3/4/5 | 2 (5.7) | 5 (15.2) | .2522 |
| Hyperglycemia | 3/4/5 | 1 (2.9) | 6 (18.2) | .0513 |
Based on Fisher’s exact test.