Patient characteristics
| . | Arm A (N = 10) . | Arm B (N = 36) . | Arm C (N = 34) . | Arm D* (N = 17) . | P value† . |
|---|---|---|---|---|---|
| Age, years, median (range) | 69 (44-73) | 64 (50-78) | 65 (47-80) | 64 (50-73) | .697 |
| Male, n (%) | 7 (70) | 23 (64) | 18 (53) | 12 (71) | .467 |
| Number of prior therapies, median (range) | 5 (4-12) | 4 (2-12) | 4 (2-9) | 4 (3-8) | .570 |
| Bortezomib refractory, n (%) | 10 (100) | 28 (78) | 24 (71) | 12 (71) | .413 |
| Carfilzomib refractory, n (%) | 1 (10) | 16 (44) | 13 (38) | 7 (41) | .632 |
| Prior HDM/ASCT,‡ n (%) | 7 (70) | 27 (75) | 28 (82) | 13 (76) | .7 |
| Prior alkylating agent, n (%) | 10 (100) | 32 (89) | 32 (94) | 15 (88) | 1.0 |
| Serum creatinine (mg/dL), median (range) | 1 (1-3) | 1 (0.5-2.3) | 0.9 (0.6-2.1) | 1 (1-2) | .650 |
| High-risk cytogenetics,§ n (%) | 3 (30) | 8 (22) | 7 (21) | 4 (23) | 1.0 |
| Deletion 17p, n (%) | 3 (30) | 6 (16) | 5 (15) | 3 (18) | .6 |
| t(4;14), n (%) | 0 | 4 (11) | 3 (9) | 3 (18) | .6 |
| Trisomy or tetrasomy 1q, n (%) | 3 (30) | 18 (50) | 9 (26) | 9 (53) | .1 |
| . | Arm A (N = 10) . | Arm B (N = 36) . | Arm C (N = 34) . | Arm D* (N = 17) . | P value† . |
|---|---|---|---|---|---|
| Age, years, median (range) | 69 (44-73) | 64 (50-78) | 65 (47-80) | 64 (50-73) | .697 |
| Male, n (%) | 7 (70) | 23 (64) | 18 (53) | 12 (71) | .467 |
| Number of prior therapies, median (range) | 5 (4-12) | 4 (2-12) | 4 (2-9) | 4 (3-8) | .570 |
| Bortezomib refractory, n (%) | 10 (100) | 28 (78) | 24 (71) | 12 (71) | .413 |
| Carfilzomib refractory, n (%) | 1 (10) | 16 (44) | 13 (38) | 7 (41) | .632 |
| Prior HDM/ASCT,‡ n (%) | 7 (70) | 27 (75) | 28 (82) | 13 (76) | .7 |
| Prior alkylating agent, n (%) | 10 (100) | 32 (89) | 32 (94) | 15 (88) | 1.0 |
| Serum creatinine (mg/dL), median (range) | 1 (1-3) | 1 (0.5-2.3) | 0.9 (0.6-2.1) | 1 (1-2) | .650 |
| High-risk cytogenetics,§ n (%) | 3 (30) | 8 (22) | 7 (21) | 4 (23) | 1.0 |
| Deletion 17p, n (%) | 3 (30) | 6 (16) | 5 (15) | 3 (18) | .6 |
| t(4;14), n (%) | 0 | 4 (11) | 3 (9) | 3 (18) | .6 |
| Trisomy or tetrasomy 1q, n (%) | 3 (30) | 18 (50) | 9 (26) | 9 (53) | .1 |