Hematologic parameters of Bmp6-Tmprss6 genotype combinations
| . | RBC × 106 cells/μL . | Hb (g/dL) . | HCT (%) . | MCV (fL) . | MCH (pg) . | RDW (%) . |
|---|---|---|---|---|---|---|
| Bmp6+/+-Tmprss6+/+ | 10.4 ± 0.9 | 17.1 ± 1.4 | 46.5 ± 4.4 | 44.6 ± 1.8 | 16.4 ± 0.7 | 27.4 ± 1.4 |
| Bmp6+/+-Tmprss6−/− | 9.5 ± 0.6 | 12.1 ± 0.8* | 30.9 ± 2.7* | 32.4 ± 1.3* | 12.7 ± 0.3* | 35.5 ± 1.4* |
| Bmp6−/−-Tmprss6+/+ | 9.5 ± 0.8 | 16.7 ± 0.8 | 44.1 ± 2.8 | 46.7 ± 1.8 | 17.8 ± 1.2 | 25.1 ± 5 |
| Bmp6−/−-Tmprss6−/− | 9.8 ± 0.8 | 16.4 ± 1.3† | 44.2 ± 3.6† | 45 ± 1.3† | 16.7 ± 0.5† | 27.5 ± 2† |
| . | RBC × 106 cells/μL . | Hb (g/dL) . | HCT (%) . | MCV (fL) . | MCH (pg) . | RDW (%) . |
|---|---|---|---|---|---|---|
| Bmp6+/+-Tmprss6+/+ | 10.4 ± 0.9 | 17.1 ± 1.4 | 46.5 ± 4.4 | 44.6 ± 1.8 | 16.4 ± 0.7 | 27.4 ± 1.4 |
| Bmp6+/+-Tmprss6−/− | 9.5 ± 0.6 | 12.1 ± 0.8* | 30.9 ± 2.7* | 32.4 ± 1.3* | 12.7 ± 0.3* | 35.5 ± 1.4* |
| Bmp6−/−-Tmprss6+/+ | 9.5 ± 0.8 | 16.7 ± 0.8 | 44.1 ± 2.8 | 46.7 ± 1.8 | 17.8 ± 1.2 | 25.1 ± 5 |
| Bmp6−/−-Tmprss6−/− | 9.8 ± 0.8 | 16.4 ± 1.3† | 44.2 ± 3.6† | 45 ± 1.3† | 16.7 ± 0.5† | 27.5 ± 2† |
Complete blood counts were measured from whole blood. Data are presented as mean ± SD. Group sizes: Bmp6+/+-Tmprss6+/+ (n = 6); Bmp6+/+-Tmprss6−/− (n = 6); Bmp6−/−-Tmprss6+/+ (n = 7); and Bmp6−/−-Tmprss6−/− (n = 5). Bmp6−/−-Tmprss6−/− mice vs Bmp6+/+-Tmprss6+/+ mice; no statistical significance was observed.
P < .0001. Bmp6+/+-Tmprss6−/− mice vs Bmp6+/+-Tmprss6+/+ mice.
P < .0001. Bmp6−/−-Tmprss6−/− mice vs Bmp6+/+-Tmprss6−/− mice.