WHO classification of mastocytosis
| WHO mastocytosis classification . |
|---|
| 1. Cutaneous mastocytosis (CM) |
| 2. Systemic mastocytosis |
| a. Indolent systemic mastocytosis (ISM)* |
| b. Smoldering systemic mastocytosis (SSM)* |
| c. Systemic mastocytosis with an associated hematological neoplasm (SM-AHN)† |
| d. Aggressive systemic mastocytosis (ASM)* |
| e. Mast cell leukemia (MCL) |
| 3. Mast cell sarcoma (MCS) |
| WHO mastocytosis classification . |
|---|
| 1. Cutaneous mastocytosis (CM) |
| 2. Systemic mastocytosis |
| a. Indolent systemic mastocytosis (ISM)* |
| b. Smoldering systemic mastocytosis (SSM)* |
| c. Systemic mastocytosis with an associated hematological neoplasm (SM-AHN)† |
| d. Aggressive systemic mastocytosis (ASM)* |
| e. Mast cell leukemia (MCL) |
| 3. Mast cell sarcoma (MCS) |
These subtypes require information regarding B and C findings for complete diagnosis,20 all of which may not be available at the time of initial tissue diagnosis.
This category is equivalent to the previously described “systemic mastocytosis with an associated clonal hematological non-mast cell lineage disease (SM-AHNMD).” AHNMD and AHN can be used synonymously.