Antibody-dependent blood loss in hemophilia A mice treated with low- vs high-dose fVIII
| Antibody . | Median blood loss (mg/g of body weight) . | Mean blood loss (mg/g of body weight) . | ||
|---|---|---|---|---|
| Low dose . | High dose . | Low dose . | High dose . | |
| No fVIII control | 42.3 | 37.6 | ||
| No MAb control | 0.9 | 0.8 | 2.5 | 7.0 |
| 2-76 | 40.3* | 38.1* | 39.1 | 38.2 |
| 4A4 | 39.7* | 31.2* | 38.2 | 32.1 |
| B94 | 3.1 | 7.7 | 8.5 | 14.6 |
| B25 | 0.6 | — | 1.4 | — |
| 2-54 | 3.3 | 2.1 | 11.2 | 14.2 |
| GMA-012 | 0.0 | 1.1 | 6.3 | 1.3 |
| 4C7 | 0.0 | — | 0.3 | — |
| 1D4 | 40.7* | 41.3* | 36.1 | 35.1 |
| Antibody . | Median blood loss (mg/g of body weight) . | Mean blood loss (mg/g of body weight) . | ||
|---|---|---|---|---|
| Low dose . | High dose . | Low dose . | High dose . | |
| No fVIII control | 42.3 | 37.6 | ||
| No MAb control | 0.9 | 0.8 | 2.5 | 7.0 |
| 2-76 | 40.3* | 38.1* | 39.1 | 38.2 |
| 4A4 | 39.7* | 31.2* | 38.2 | 32.1 |
| B94 | 3.1 | 7.7 | 8.5 | 14.6 |
| B25 | 0.6 | — | 1.4 | — |
| 2-54 | 3.3 | 2.1 | 11.2 | 14.2 |
| GMA-012 | 0.0 | 1.1 | 6.3 | 1.3 |
| 4C7 | 0.0 | — | 0.3 | — |
| 1D4 | 40.7* | 41.3* | 36.1 | 35.1 |
P < .05, MAb vs no MAb control, Mann-Whitney U test.