Clonality, and IHC characterization of the LBCL PDX models
| Model ID . | Clonality . | Diagnosis . | IHC, % (intensity) . | |||||
|---|---|---|---|---|---|---|---|---|
| CD20 . | CD10 . | MUM1 . | BCL6 . | BCL2 . | MYC . | |||
| LTL-005 | Yes (mono, FR1) | DLBCL | 100 | Negative | 70 (3+) | 60 (2+) | Negative | 40 |
| LTL-013 | Yes (mono, FR2) | DLBCL | 90 | Negative | 10 (3+) | 20 (1+) | 10 (1+) | 80 |
| LTL-014 | Yes (mono, FR2) | DLBCL | 5 | 90 (2+) | 80 (2+) | 30( 2+) | Negative | 99 |
| LTL-025 | Yes (mono, FR2) | DLBCL | 100 | Negative | 100 (3+) | 40 (1+) | 90 (2+) | 90 |
| LTL-026 | Yes (mono, FR2) | DLBCL | 100 | Negative | 50 (3+) | 80 (2+) | 70 (1+) | 90 |
| LTL-030 | Yes (mono, FR2) | DLBCL | 100 | 100 (2+) | Negative | 90 (3+) | 90 (3+) | 10 |
| LTL-034 | Yes (mono, FR2) | DLBCL | 100 | Negative | 100 (3+) | 50 (1+) | 9 (1+) | 70 |
| LTL-037 | Yes (bl, FR1) | DLBCL | 70* | Negative | 70 (3+) | Negative | Negative | 40 |
| LTL-048 | Yes (mono, FR1) | PBL | Negative | 20 (1+) | 100 (3+) | Negative | Negative | 50 |
| Model ID . | Clonality . | Diagnosis . | IHC, % (intensity) . | |||||
|---|---|---|---|---|---|---|---|---|
| CD20 . | CD10 . | MUM1 . | BCL6 . | BCL2 . | MYC . | |||
| LTL-005 | Yes (mono, FR1) | DLBCL | 100 | Negative | 70 (3+) | 60 (2+) | Negative | 40 |
| LTL-013 | Yes (mono, FR2) | DLBCL | 90 | Negative | 10 (3+) | 20 (1+) | 10 (1+) | 80 |
| LTL-014 | Yes (mono, FR2) | DLBCL | 5 | 90 (2+) | 80 (2+) | 30( 2+) | Negative | 99 |
| LTL-025 | Yes (mono, FR2) | DLBCL | 100 | Negative | 100 (3+) | 40 (1+) | 90 (2+) | 90 |
| LTL-026 | Yes (mono, FR2) | DLBCL | 100 | Negative | 50 (3+) | 80 (2+) | 70 (1+) | 90 |
| LTL-030 | Yes (mono, FR2) | DLBCL | 100 | 100 (2+) | Negative | 90 (3+) | 90 (3+) | 10 |
| LTL-034 | Yes (mono, FR2) | DLBCL | 100 | Negative | 100 (3+) | 50 (1+) | 9 (1+) | 70 |
| LTL-037 | Yes (bl, FR1) | DLBCL | 70* | Negative | 70 (3+) | Negative | Negative | 40 |
| LTL-048 | Yes (mono, FR1) | PBL | Negative | 20 (1+) | 100 (3+) | Negative | Negative | 50 |
Two populations by CD20 intensity.